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| Target General Information |
Top |
| Target ID |
T00033 |
Target Info
|
| Target Name |
Transforming growth factor alpha (TGFA) |
| Synonyms |
TGF-alpha (40-89); TGF type 1 (40-89); Protransforming growth factor alpha (40-89); ETGF (40-89); EGF-like TGF (40-89) |
| Target Type |
Clinical trial Target |
| Gene Name |
TGFA |
| Biochemical Class |
Growth factor |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Epidermal growth factor receptor (EGFR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Co-crystal Structure |
[1] |
| 2 |
Protein-Fragment Complementation Assay |
[2] |
| 3 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell. 2002 Sep 20;110(6):763-73.
|
| REF 2 |
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
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| REF 3 |
In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
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