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Target General Information |
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Target ID |
T02001 |
Target Info
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Target Name |
Phosphodiesterase 4D (PDE4D) |
Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D; PDE43; DPDE3 |
Target Type |
Successful Target |
Gene Name |
PDE4D |
Biochemical Class |
Phosphoric diester hydrolase |
UniProt ID |
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Target Interacting Proteins |
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Auxiliary transporters |
[+] 1 Auxiliary transporters |
+ |
Interacting Target Name |
Receptor of activated protein C kinase 1 (RACK1) |
Literature-reported Target |
Interacting Protein Info
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UniProt ID |
|
Synonyms |
Small ribosomal subunit protein RACK1; Receptor of activated protein C kinase 1, N-terminally processed; Receptor for activated C kinase; Human lung cancer oncogene 7 protein; HLC-7; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Guanine nucleotide-binding protein subunit beta-2-like 1; GNB2L1; Cell proliferation-inducing gene 21 protein |
Evidence Score (E-score) |
3 Experimental Evidences |
+ |
1 |
Affinity Capture-Western |
[1] |
2 |
Yeast two hybrid |
[2] |
3 |
Yeast two hybrid |
[3] |
References |
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REF 1 |
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem. 2009 Jun 12;284(24):16170-82.
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REF 2 |
The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. J Biol Chem. 1999 May 21;274(21):14909-17.
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REF 3 |
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5. BMC Biochem. 2002 Aug 23;3:24.
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