Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T02532 Target Info
Target Name T-cell surface antigen CD2 (CD2)
Synonyms T-cell surface antigen T11/Leu-5; SRBC; Rosette receptor; LFA-3 receptor; LFA-2; Erythrocyte receptor
Target Type Clinical trial Target
Gene Name CD2
UniProt ID
CD2_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name SH3 domain-containing kinase-binding protein 1 (SH3KBP1) Interacting Protein Interacting Protein Info
UniProt ID
SH3K1_HUMAN 
Synonyms CD2BP3; CIN85; GIG10; HSB.1; HSB1; MIG18
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-crystal Structure [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
4 Yeast two hybrid [3]
Other proteins [+] 2 Other proteins +
Interacting Protein Name CD2-associated protein (CD2AP) Interacting Protein Interacting Protein Info
UniProt ID
CD2AP_HUMAN 
Synonyms CMS
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
Interacting Target Name Surface glycoprotein LFA-3 (CD58) Successful Target Interacting Protein Info
UniProt ID
LFA3_HUMAN 
Synonyms Surface glycoprotein LFA3; Lymphocyte function-associated antigen 3; Lymphocyte functionassociated antigen 3; LFA3; Ag3
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [4]
2 Reconstituted Complex [5]
References  Top
REF 1 Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*. FEBS J. 2013 Jul;280(14):3399-415.
REF 2 Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. J Biol Chem. 2003 Jun 20;278(25):22396-403.
REF 3 CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities. Int Immunol. 2003 Mar;15(3):313-29.
REF 4 Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional "hot spot". J Mol Biol. 2001 Sep 28;312(4):711-20.
REF 5 A secreted protein microarray platform for extracellular protein interaction discovery. Anal Biochem. 2012 Jan 15;420(2):127-38.

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