Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05031 | Target Info | |||
| Target Name | PI3-kinase beta (PIK3CB) | ||||
| Synonyms | p110beta; PtdIns3kinase subunit p110beta; PtdIns3kinase subunit beta; PtdIns-3-kinase subunit p110-beta; PtdIns-3-kinase subunit beta; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunitbeta isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalyticsubunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PIK3C1; PI3kinase subunit beta; PI3Kbeta; PI3K-beta; PI3-kinase subunit beta | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PIK3CB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Adapter proteins | [+] 1 Adapter proteins | + | |||
| Interacting Protein Name | Growth factor receptor-bound protein 2 (GRB2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2 | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Protein Name | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | AGM7; GRB1; IMD36; p85; p85.ALPHA | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [2] | |||
| 2 | Co-fractionation | [3] | |||
| 3 | Yeast two hybrid | [4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 2 | Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. Mol Cell Biol. 1994 Apr;14(4):2577-83. | ||||
| REF 3 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
| REF 4 | Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863. | ||||
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