Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T08919 Target Info
Target Name Epithelial cadherin (CDH1)
Synonyms Uvomorulin; UVO; E-cadherin gene; E-cadherin; Cadherin-1; CDHE; CD324; CAM 120/80
Target Type Literature-reported Target
Gene Name CDH1
UniProt ID
CADH1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Target Name Endoplasmic reticulum chaperone BiP (HSPA5) Clinical trial Target Interacting Protein Info
UniProt ID
BIP_HUMAN 
Synonyms Immunoglobulin heavy chain-binding protein; Immunoglobulin heavy chainbinding protein; HSP70 family protein 5; Heat shock protein family A member 5; Heat shock protein 70 family protein 5; Heat shock 70 kDa protein 5; GRP-78; GRP78; Endoplasmic reticulum lumenal Ca(2+)binding protein grp78; BiP; Binding-immunoglobulin protein; 78 kDa glucose-regulated protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Proximity Label-MS [2]
Interacting Protein Name Unconventional myosin-VI (MYO6) Interacting Protein Interacting Protein Info
UniProt ID
MYO6_HUMAN 
Synonyms DFNA22; DFNB37
Evidence Score (E-score) 2 Experimental Evidences +
1 Proximity Label-MS [2]
2 Reconstituted Complex [3]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase Hakai (CBLL1) Interacting Protein Interacting Protein Info
UniProt ID
HAKAI_HUMAN 
Synonyms HAKAI; RNF188
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Co-localization [9]
7 Fluorescence Resonance Energy Transfer [10]
8 Yeast two hybrid [4]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Proximity Label-MS [2]
Histones [+] 1 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [11]
2 Proximity Label-MS [2]
Intermediate filaments [+] 1 Intermediate filaments +
Interacting Protein Name Cytokeratin-18 (KRT18) Interacting Protein Interacting Protein Info
UniProt ID
K1C18_HUMAN 
Synonyms CYK18; K18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Proximity Label-MS [2]
Kinases [+] 3 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Proximity Label-MS [2]
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Proximity Label-MS [2]
Interacting Protein Name Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C) Interacting Protein Interacting Protein Info
UniProt ID
PI51C_HUMAN 
Synonyms LCCS3; PIP5K.GAMMA; PIP5K1.gamma; PIP5Kgamma
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Fluorescence Resonance Energy Transfer [10]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Reconstituted Complex [15]
Other proteins [+] 9 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [17]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [19]
6 Affinity Capture-Western [20]
7 Affinity Capture-Western [21]
8 Affinity Capture-Western [22]
9 Affinity Capture-Western [23]
10 Affinity Capture-Western [24]
11 Affinity Capture-Western [25]
12 Affinity Capture-Western [26]
13 Affinity Capture-Western [27]
14 Affinity Capture-Western [28]
15 Affinity Capture-Western [29]
16 Affinity Capture-Western [30]
17 Affinity Capture-Western [31]
18 Affinity Capture-Western [32]
19 Affinity Capture-Western [33]
20 Affinity Capture-Western [34]
Interacting Protein Name Catenin delta-1 (CTNND1) Interacting Protein Interacting Protein Info
UniProt ID
CTND1_HUMAN 
Synonyms CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN)
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [35]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [25]
5 Affinity Capture-Western [28]
6 Affinity Capture-Western [34]
7 Affinity Capture-Western [36]
8 Co-crystal Structure [37]
9 Co-localization [37]
10 Fluorescence Resonance Energy Transfer [10]
11 Proximity Label-MS [2]
12 Reconstituted Complex [38]
13 Reconstituted Complex [37]
14 Yeast two hybrid [35]
Interacting Target Name Junction plakoglobin (JUP) Literature-reported Target Interacting Protein Info
UniProt ID
PLAK_HUMAN 
Synonyms Plakoglobin; DP3; Desmoplakin-3; Desmoplakin III; CTNNG; Catenin gamma
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [25]
4 Affinity Capture-Western [14]
5 Affinity Capture-Western [40]
6 Proximity Label-MS [2]
Interacting Protein Name Catenin alpha-1 (CTNNA1) Interacting Protein Interacting Protein Info
UniProt ID
CTNA1_HUMAN 
Synonyms CAP102
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [18]
3 Affinity Capture-Western [19]
4 Affinity Capture-Western [20]
5 Affinity Capture-Western [21]
6 Proximity Label-MS [2]
Interacting Protein Name Vinculin (VCL) Interacting Protein Interacting Protein Info
UniProt ID
VINC_HUMAN 
Synonyms CMD1W; CMH15; HEL114; MV; MVCL
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Affinity Capture-Western [25]
3 Proximity Label-MS [2]
Interacting Target Name Cytovillin (EZR) Literature-reported Target Interacting Protein Info
UniProt ID
EZRI_HUMAN 
Synonyms Villin-2; VIL2; p81; Cytovillin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Proximity Label-MS [2]
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [42]
2 Biochemical Activity [43]
Interacting Protein Name Ras GTPase-activating-like protein IQGAP1 (IQGAP1) Interacting Protein Interacting Protein Info
UniProt ID
IQGA1_HUMAN 
Synonyms HUMORFA01; SAR1; p195
Evidence Score (E-score) 2 Experimental Evidences +
1 Proximity Label-MS [2]
2 Reconstituted Complex [44]
Interacting Protein Name Protein NDRG1 (NDRG1) Interacting Protein Interacting Protein Info
UniProt ID
NDRG1_HUMAN 
Synonyms CAP43; CMT4D; DRG.1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [30]
2 Proximity Label-MS [2]
References  Top
REF 1 Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. J Proteome Res. 2005 Sep-Oct;4(5):1646-56.
REF 2 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal. 2014 Dec 2;7(354):rs7.
REF 3 The juxtamembrane domain of the E-cadherin cytoplasmic tail contributes to its interaction with Myosin VI. Bioarchitecture. 2012 Sep-Oct;2(5):185-8.
REF 4 Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol. 2002 Mar;4(3):222-31.
REF 5 Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells. Exp Cell Res. 2006 Feb 1;312(3):331-9.
REF 6 Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis. Oncogene. 2012 Jan 19;31(3):376-89.
REF 7 An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin. J Cell Biochem. 2009 Nov 1;108(4):851-9.
REF 8 Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent. PLoS One. 2012;7(6):e38441.
REF 9 Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway. J Biol Chem. 2008 Feb 22;283(8):5127-37.
REF 10 The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC. Eur J Hum Genet. 2013 Mar;21(3):301-9.
REF 11 UHRF1 regulates CDH1 via promoter associated non-coding RNAs in prostate cancer cells. Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):258-270.
REF 12 Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem. 2000 Dec 29;275(52):41227-33.
REF 13 Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells. Lab Invest. 2000 Mar;80(3):387-94.
REF 14 Multiple post-translational modifications regulate E-cadherin transport during apoptosis. J Cell Sci. 2012 Jun 1;125(Pt 11):2615-25.
REF 15 MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol Cell Biol. 2006 Oct;26(19):7269-82.
REF 16 Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells. J Biol Chem. 2014 Sep 12;289(37):25431-44.
REF 17 Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. Cancer Res. 2001 Feb 15;61(4):1671-7.
REF 18 Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol. 1995 Jul;130(2):461-71.
REF 19 UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002 Mar 27;21(13):2037-50.
REF 20 Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. J Cell Sci. 1993 Aug;105 ( Pt 4):923-34.
REF 21 Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence. Oncogene. 1997 Jul 3;15(1):71-8.
REF 22 HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells. Int J Mol Med. 2001 Apr;7(4):385-8.
REF 23 Vinculin is associated with the E-cadherin adhesion complex. J Biol Chem. 1997 Dec 19;272(51):32448-53.
REF 24 CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells. Biochem Biophys Res Commun. 2002 Jun 21;294(4):900-5.
REF 25 The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem. 1998 Apr 10;273(15):9078-84.
REF 26 Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol. 1998 Dec;18(12):7216-24.
REF 27 MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures. Biochem Biophys Res Commun. 2000 Apr 21;270(3):903-9.
REF 28 Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol. 1995 Mar;128(5):949-57.
REF 29 Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J. 2002 Dec 1;368(Pt 2):471-81.
REF 30 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Mol Cell Proteomics. 2007 Apr;6(4):575-88.
REF 31 Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion. Biochem Biophys Res Commun. 2005 Oct 14;336(1):247-51.
REF 32 Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J Biol Chem. 2006 Jun 2;281(22):15423-33.
REF 33 Acute and chronic cadmium exposure promotes E-cadherin degradation in MCF7 breast cancer cells. Mol Carcinog. 2015 Oct;54(10):1014-25.
REF 34 P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model. J Pathol. 2013 Apr;229(5):705-18.
REF 35 The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol. 1995 Sep;15(9):4819-24.
REF 36 Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis. Hum Mol Genet. 2012 Oct 1;21(19):4253-69.
REF 37 Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell. 2010 Apr 2;141(1):117-28.
REF 38 p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol. 2003 Apr;23(7):2287-97.
REF 39 Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol. 1994 Jun;125(6):1327-40.
REF 40 Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J Cell Biol. 1992 Aug;118(3):671-9.
REF 41 Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin. J Cell Sci. 1999 Sep;112 Pt 18:3081-90.
REF 42 Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol. 2011 Feb;226(2):407-13.
REF 43 Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget. 2015 Oct 27;6(33):34953-67.
REF 44 IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem. 1999 Dec 31;274(53):37885-92.

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