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| Target General Information |
Top |
| Target ID |
T12091 |
Target Info
|
| Target Name |
Activin receptor-like kinase 2 (ALK-2) |
| Synonyms |
TSR-I; TGF-B superfamily receptor type I; Serine/threonine-protein kinase receptor R1; SKR1; Activin receptor type-1; Activin receptor type I; ACVRLK2; ACTR-I |
| Target Type |
Clinical trial Target |
| Gene Name |
ACVR1 |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 2 Kinases |
+ |
| Interacting Target Name |
Bone morphogenetic protein receptor (BMPR2) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II; BMPR-II; BMPR-2; BMP type-2 receptor; BMP type II receptor |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Yeast two hybrid |
[2] |
| Interacting Protein Name |
Bone morphogenetic protein receptor type-1A (BMPR1A) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
10q23del; ACVRLK3; ALK3; CD292; SKR5 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-MS |
[3] |
| 3 |
Fluorescence Resonance Energy Transfer |
[4] |
| References |
Top |
| REF 1 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
|
| REF 2 |
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol. 1995 Jul;15(7):3479-86.
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| REF 3 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
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| REF 4 |
BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem. 2008 Jul 25;283(30):20948-58.
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