Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12499 Target Info
Target Name LCK tyrosine protein kinase (LCK)
Synonyms p56-LCK; Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; Lymphocyte cell-specific protein-tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; LCK p59-Fyn; LCK Protooncogene Syn
Target Type Successful Target
Gene Name LCK
Biochemical Class Kinase
UniProt ID
LCK_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Leukocyte common antigen (PTPRC) Clinical trial Target Interacting Protein Info
UniProt ID
PTPRC_HUMAN 
Synonyms T200; Receptor-type tyrosine-protein phosphatase C; L-CA; CD45 antigen; CD45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
Kinases [+] 1 Kinases +
Interacting Target Name PI3-kinase alpha (PIK3CA) Successful Target Interacting Protein Info
UniProt ID
PK3CA_HUMAN 
Synonyms Serine/threonine protein kinase PIK3CA; PtdIns-3-kinase subunit p110-alpha; PtdIns3kinase subunit p110alpha; PtdIns-3-kinase subunit alpha; PtdIns3kinase subunit alpha; PI3-kinase subunit alpha; PI3kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; p110alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
Other proteins [+] 6 Other proteins +
Interacting Target Name T-cell surface glycoprotein CD4 (CD4) Successful Target Interacting Protein Info
UniProt ID
CD4_HUMAN 
Synonyms T-cell surface antigen T4/Leu-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [9]
3 Yeast two hybrid [10]
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [2]
3 Protein-peptide [12]
Interacting Target Name Extracellular matrix receptor III (CD44) Clinical trial Target Interacting Protein Info
UniProt ID
CD44_HUMAN 
Synonyms Phagocytic glycoprotein I; Phagocytic glycoprotein 1; PGP-I; PGP-1; MIC4; MDU3; MDU2; LHR; Hyaluronate receptor; HUTCH-I; Hermes antigen; Heparan sulfate proteoglycan; GP90 lymphocyte homing/adhesion receptor; Extracellular matrix receptor-III; Epican; ECMR-III; CDw44; CD44 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Co-fractionation [14]
Interacting Target Name Wiskott-Aldrich syndrome protein (WAS) Clinical trial Target Interacting Protein Info
UniProt ID
WASP_HUMAN 
Synonyms WASp; IMD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Biochemical Activity [15]
Interacting Protein Name Linker for activation of T-cells family member 1 (LAT) Interacting Protein Interacting Protein Info
UniProt ID
LAT_HUMAN 
Synonyms LAT1; pp36
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [16]
2 Co-fractionation [17]
Interacting Protein Name Src kinase-associated phosphoprotein 1 (SKAP1) Interacting Protein Interacting Protein Info
UniProt ID
SKAP1_HUMAN 
Synonyms HEL.S.81p; SCAP1; SKAP55
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [19]
References  Top
REF 1 Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3794-9.
REF 2 A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions. Gene. 2005 Oct 10;359:18-25.
REF 3 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem. 1996 Apr 5;271(14):8435-42.
REF 4 CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line. J Biol Chem. 1993 Apr 25;268(12):8958-64.
REF 5 Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro. J Biol Chem. 1996 Jan 19;271(3):1295-300.
REF 6 The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem. 2004 Jan 23;279(4):2937-44.
REF 7 Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase. Mol Cell Biol. 1993 Dec;13(12):7708-17.
REF 8 Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: compariso... J Am Soc Mass Spectrom. 2004 Apr;15(4):558-67.
REF 9 The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. Biochim Biophys Acta. 2002 Apr 3;1589(2):140-50.
REF 10 The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Apoptosis. 2007 Oct;12(10):1879-92.
REF 11 Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. EMBO Rep. 2006 Oct;7(10):1023-9.
REF 12 Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. Biochemistry. 2005 Nov 15;44(45):15042-52.
REF 13 Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes. J Biol Chem. 1996 Feb 2;271(5):2863-7.
REF 14 CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes. Blood. 1998 May 15;91(10):3901-8.
REF 15 Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006 Feb 10;281(6):3513-20.
REF 16 Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes. Leuk Res. 2007 Apr;31(4):541-5.
REF 17 CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor. J Biol Chem. 2003 Dec 12;278(50):50791-802.
REF 18 Molecular alterations of the Fyn-complex occur as late events of human T cell activation. Eur J Immunol. 1999 Apr;29(4):1175-87.
REF 19 Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. J Biol Chem. 1997 Jun 27;272(26):16077-80.

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