Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13714 | Target Info | |||
| Target Name | Oxysterols receptor LXR-beta (NR1H2) | ||||
| Synonyms | Ubiquitously-expressed nuclear receptor; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor NER; Nuclear orphan receptor LXR-beta; NER; Liver X receptor beta; LXRbeta; LXRB | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NR1H2 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Nuclear hormone receptors | [+] 2 Nuclear hormone receptors | + | |||
| Interacting Target Name | Retinoic acid receptor RXR-gamma (RXRG) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Yeast two hybrid | [1] | |||
| 2 | Yeast two hybrid | [2] | |||
| Interacting Target Name | Retinoic acid receptor RXR-beta (RXRB) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [3] | |||
| 2 | Yeast two hybrid | [2] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Protein Name | Nuclear receptor corepressor 2 (NCOR2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [4] | |||
| 2 | Yeast two hybrid | [2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8. | ||||
| REF 2 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
| REF 3 | Identification of a novel DNA binding site for nuclear orphan receptor OR1. J Biol Chem. 1999 Apr 9;274(15):10421-9. | ||||
| REF 4 | Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol. 2006 Jan;69(1):99-108. | ||||
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