Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T14592 Target Info
Target Name Apoptosis mediating surface antigen FAS (FAS)
Synonyms Tumor necrosis factor receptor superfamily member 6; TNFRSF6; FASLG receptor; FAS1; CD95; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; APT1
Target Type Clinical trial Target
Gene Name FAS
Biochemical Class Cytokine receptor
UniProt ID
TNR6_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Transforming protein RhoA (RHOA) Discontinued Target Interacting Protein Info
UniProt ID
RHOA_HUMAN 
Synonyms Transforming protein RhoA; RHO12; Rho cDNA clone 12; h12; ARHA; ARH12
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [1]
2 Co-purification [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name SUMO-conjugating enzyme UBC9 (UBE2I) Interacting Protein Interacting Protein Info
UniProt ID
UBC9_HUMAN 
Synonyms C358B7.1; P18; UBC9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Yeast two hybrid [4]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name FAS-associated death domain protein (FADD) Interacting Protein Interacting Protein Info
UniProt ID
FADD_HUMAN 
Synonyms MORT1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Co-purification [2]
Kinases [+] 1 Kinases +
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [1]
2 Co-purification [2]
Peptidases [+] 2 Peptidases +
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [7]
3 Co-purification [2]
Interacting Target Name Caspase-10 (CASP10) Patented-recorded Target Interacting Protein Info
UniProt ID
CASPA_HUMAN 
Synonyms MCH4; ICE-like apoptotic protease 4; FLICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP-10; Apoptotic protease Mch-4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-purification [2]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Co-localization [1]
3 Reconstituted Complex [10]
4 Yeast two hybrid [11]
Interacting Target Name Apoptosis antigen ligand (CD178) Literature-reported Target Interacting Protein Info
UniProt ID
TNFL6_HUMAN 
Synonyms Tumor necrosis factor ligand superfamily member 6; TNFSF6; FasL; Fas ligand; FAS antigen ligand; CD95-L; CD95L; CD95 ligand; CD178 antigen; CD178; APTL; APT1LG1; Apoptosis antigen ligand
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [1]
2 Co-purification [2]
3 Reconstituted Complex [12]
Interacting Protein Name FAS-associated factor 1 (FAF1) Interacting Protein Interacting Protein Info
UniProt ID
FAF1_HUMAN 
Synonyms HFAF1s; UBXD12; UBXN3A; hFAF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Yeast two hybrid [14]
References  Top
REF 1 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 2 Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005 Mar 25;280(12):11641-7.
REF 3 Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway. FEBS Lett. 1997 Jul 21;412(1):102-6.
REF 4 Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP). J Biol Chem. 1996 Dec 6;271(49):31037-43.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem. 2001 Jan 26;276(4):2668-77.
REF 7 Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751-63.
REF 8 Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J Biol Chem. 1997 Mar 7;272(10):6578-83.
REF 9 Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. J Biol Chem. 2001 Oct 19;276(42):39103-6.
REF 10 Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 1997 Jun 27;89(7):1067-76.
REF 11 Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. J Biol Chem. 2002 Mar 8;277(10):7955-61.
REF 12 Identification of amino acid residues important for ligand binding to Fas. J Exp Med. 1997 Apr 21;185(8):1487-92.
REF 13 A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11894-8.
REF 14 Identification and characterization of human Fas associated factor 1, hFAF1. Biochem Biophys Res Commun. 1999 Aug 27;262(2):388-94.

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