Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16459 Target Info
Target Name CDK inhibitor 1C p57Kip2 (CDKN1C)
Synonyms P57KIP2; P57(KIP2); KIP2; Cyclin-dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C
Target Type Literature-reported Target
Gene Name CDKN1C
UniProt ID
CDN1C_HUMAN 
Target Interacting Proteins  Top
Cell cycle related proteins [+] 2 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [1]
Interacting Target Name Cyclin A2 (CCNA2) Literature-reported Target Interacting Protein Info
UniProt ID
CCNA2_HUMAN 
Synonyms Cyclin-A2; Cyclin-A; Cyclin A; CCNA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Other proteins [+] 1 Other proteins +
Interacting Target Name S-phase kinase-associated protein 2 (SKP2) Literature-reported Target Interacting Protein Info
UniProt ID
SKP2_HUMAN 
Synonyms Skp2; P45skp2; FBXL1; F-box/LRR-repeat protein 1; F-box protein Skp2; Cyclin-A/CDK2-associated protein p45; Cyclin A/CDK2-associated protein p45; Cyclin A/CDK2-associated p45
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [6]
References  Top
REF 1 Dimerization of the amino terminal domain of p57Kip2 inhibits cyclin D1-cdk4 kinase activity. Oncogene. 2000 Feb 24;19(9):1147-52.
REF 2 Stabilization of MyoD by direct binding to p57(Kip2). J Biol Chem. 2000 Jun 23;275(25):18767-76.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. J Biol Chem. 2003 Nov 7;278(45):44255-64.
REF 5 SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. Gastroenterology. 2009 Nov;137(5):1816-26.e1-10.
REF 6 Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10231-6.

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