Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16808 Target Info
Target Name Protein arginine methyltransferase 1 (PRMT1)
Synonyms Protein arginine N-methyltransferase 1; Interferon receptor 1-bound protein 4; IR1B4; Histone-arginine N-methyltransferase PRMT1; HRMT1L2; HMT2
Target Type Clinical trial Target
Gene Name PRMT1
Biochemical Class Methyltransferase
UniProt ID
ANM1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
Other proteins [+] 5 Other proteins +
Interacting Target Name GAP-associated tyrosine phosphoprotein p62 (KHDRBS1) Literature-reported Target Interacting Protein Info
UniProt ID
KHDR1_HUMAN 
Synonyms Src-associated in mitosis 68 kDa protein; Srcassociated in mitosis 68 kDa protein; Sam68; p68; p21 Ras GTPase-activating protein-associated p62; p21 Ras GTPaseactivating proteinassociated p62; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KH domaincontaining, RNAbinding, signal transductionassociated protein 1; GAPassociated tyrosine phosphoprotein p62
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Biochemical Activity [5]
4 Biochemical Activity [6]
Interacting Protein Name Interleukin enhancer-binding factor 3 (ILF3) Interacting Protein Interacting Protein Info
UniProt ID
ILF3_HUMAN 
Synonyms CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4; NF.AT.90; NF110; NF110b; NF90; NF90a; NF90b; NFAR; NFAR.1; NFAR2; TCP110; TCP80
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [7]
3 Biochemical Activity [8]
4 Yeast two hybrid [7]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) Interacting Protein Interacting Protein Info
UniProt ID
ROA1_HUMAN 
Synonyms Single-strand RNA-binding protein; HNRPA1; hnRNP core protein A1; hnRNP A1; Heterogeneous nuclear ribonucleoprotein A1; Helix-destabilizing protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [9]
2 Biochemical Activity [10]
3 Biochemical Activity [6]
4 Reconstituted Complex [10]
Interacting Protein Name Protein BTG2 (BTG2) Interacting Protein Interacting Protein Info
UniProt ID
BTG2_HUMAN 
Synonyms PC3; TIS21
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [11]
2 Reconstituted Complex [9]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein R (HNRNPR) Interacting Protein Interacting Protein Info
UniProt ID
HNRPR_HUMAN 
Synonyms HNRPR; hnRNP.R
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [12]
2 Yeast two hybrid [13]
References  Top
REF 1 Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol. 2008 Mar 28;377(3):668-78.
REF 2 Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron. J Cell Sci. 2017 Oct 15;130(20):3578-3587.
REF 3 Arginine methylation regulates telomere length and stability. Mol Cell Biol. 2009 Sep;29(18):4918-34.
REF 4 Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol. 2007 Oct;9(10):1208-15.
REF 5 Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003 Jan;14(1):274-87.
REF 6 hCAF1, a new regulator of PRMT1-dependent arginine methylation. J Cell Sci. 2007 Feb 15;120(Pt 4):638-47.
REF 7 Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. J Biol Chem. 2000 Jun 30;275(26):19866-76.
REF 8 PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep. 2002 Mar;3(3):268-73.
REF 9 The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem. 1996 Jun 21;271(25):15034-44.
REF 10 Physical and functional interactions between hnRNP K and PRMT family proteins. FEBS Lett. 2009 Jan 22;583(2):281-6.
REF 11 Btg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylation. Mol Cell Biol. 2006 Jul;26(13):5023-32.
REF 12 Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochim Biophys Acta. 2002 Aug 19;1591(1-3):1-10.
REF 13 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.

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