Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16886 Target Info
Target Name GAP SH3 domain-binding protein 1 (G3BP1)
Synonyms hDH VIII; Ras GTPase-activating protein-binding protein 1; G3BP-1; G3BP; ATP-dependent DNA helicase VIII
Target Type Literature-reported Target
Gene Name G3BP1
Biochemical Class Acid anhydride hydrolase
UniProt ID
G3BP1_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Enhancer of-decapping protein 4 (EDC4) Interacting Protein Interacting Protein Info
UniProt ID
EDC4_HUMAN 
Synonyms GE1; Ge.1; HEDL5; HEDLS; RCD.8; RCD8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 10 (USP10) Interacting Protein Interacting Protein Info
UniProt ID
UBP10_HUMAN 
Synonyms UBPO
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [6]
6 Reconstituted Complex [7]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Caprin-1 (CAPRIN1) Interacting Protein Interacting Protein Info
UniProt ID
CAPR1_HUMAN 
Synonyms GPIAP1; GPIP137; GRIP137; M11S1; RNG105; p137GPI
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [5]
4 Reconstituted Complex [8]
References  Top
REF 1 ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell. 2016 Jan 28;164(3):487-98.
REF 2 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 3 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 4 Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Oncogene. 2001 Jun 28;20(29):3869-79.
REF 5 G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28;212(7):845-60.
REF 6 Stress granules inhibit apoptosis by reducing reactive oxygen species production. Mol Cell Biol. 2013 Feb;33(4):815-29.
REF 7 Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. 2015 May 14;34(20):2660-71.
REF 8 Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs. Mol Cell Biol. 2007 Mar;27(6):2324-42.

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