Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17067 Target Info
Target Name Isopeptidase T (USP5)
Synonyms Ubiquitin-specific-processing protease 5; Ubiquitin thioesterase 5; Ubiquitin carboxyl-terminal hydrolase 5; ISOT; Deubiquitinating enzyme 5
Target Type Preclinical Target
Gene Name USP5
Biochemical Class Peptidase
UniProt ID
UBP5_HUMAN 
Target Interacting Proteins  Top
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 15 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Biochemical Activity [4]
5 Biochemical Activity [5]
6 Biochemical Activity [6]
7 Co-crystal Structure [7]
8 Protein-peptide [8]
9 Reconstituted Complex [9]
10 Reconstituted Complex [10]
11 Reconstituted Complex [7]
12 Reconstituted Complex [11]
13 Reconstituted Complex [12]
14 Reconstituted Complex [13]
15 Reconstituted Complex [14]
References  Top
REF 1 Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. PLoS One. 2011;6(12):e29362.
REF 2 Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009 May;10(5):466-73.
REF 3 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
REF 4 Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
REF 5 Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins. Structure. 2016 Mar 1;24(3):423-36.
REF 6 Method for the Purification of Endogenous Unanchored Polyubiquitin Chains. Methods Mol Biol. 2016;1449:203-13.
REF 7 The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell. 2006 Mar 24;124(6):1197-208.
REF 8 A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
REF 9 Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J Biol Chem. 2008 Jul 11;283(28):19581-92.
REF 10 Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol. 2005 Aug;12(8):708-14.
REF 11 Kinetic studies on the inhibition of isopeptidase T by ubiquitin aldehyde. Biochemistry. 1996 Oct 1;35(39):12893-900.
REF 12 USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation. Elife. 2014;3:e01369.
REF 13 Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry. Protein Sci. 2015 Aug;24(8):1257-63.
REF 14 Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions. Nat Commun. 2016 Nov 16;7:13288.

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