Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17143 Target Info
Target Name ERK activator kinase 5 (MAP2K5)
Synonyms PRKMK5; Mitogen-activatedprotein kinase kinase 5; MKK5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase5; MAP kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5
Target Type Literature-reported Target
Gene Name MAP2K5
Biochemical Class Kinase
UniProt ID
MP2K5_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Kinases [+] 3 Kinases +
Interacting Target Name MAPK/ERK kinase kinase 2 (MAP3K2) Clinical trial Target Interacting Protein Info
UniProt ID
M3K2_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [4]
5 Yeast two hybrid [5]
Interacting Target Name Extracellular signal-regulated kinase 5 (ERK5) Patented-recorded Target Interacting Protein Info
UniProt ID
MK07_HUMAN 
Synonyms PRKM7; Mitogen-activated protein kinase 7; MAPK 7; MAP kinase 7; ERK-5; BMK-1; BMK1; Big MAP kinase 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Biochemical Activity [4]
3 Reconstituted Complex [6]
4 Reconstituted Complex [4]
5 Yeast two hybrid [6]
Interacting Target Name MAPK/ERK kinase kinase 3 (MAP3K3) Literature-reported Target Interacting Protein Info
UniProt ID
M3K3_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [3]
3 Yeast two hybrid [7]
References  Top
REF 1 PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 2010 Jan 15;285(3):2077-89.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem. 2001 Feb 16;276(7):5093-100.
REF 4 Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
REF 5 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 6 Components of a new human protein kinase signal transduction pathway. J Biol Chem. 1995 May 26;270(21):12665-9.
REF 7 Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem. 2003 Sep 5;278(36):34568-81.

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