Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17986 Target Info
Target Name Enhancer of zeste homolog 1 (EZH1)
Synonyms KIAA0388; Histone-lysine N-methyltransferase EZH1; ENX-2
Target Type Clinical trial Target
Gene Name EZH1
Biochemical Class Methyltransferase
UniProt ID
EZH1_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Target Name Embryonic ectoderm development protein (EED) Clinical trial Target Interacting Protein Info
UniProt ID
EED_HUMAN 
Synonyms WD protein associating with integrin cytoplasmic tails 1; WAIT-1; hEED; Embryonic ectoderm development protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [5]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Polycomb protein SUZ12 (SUZ12) Interacting Protein Interacting Protein Info
UniProt ID
SUZ12_HUMAN 
Synonyms CHET9; JJAZ1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
References  Top
REF 1 A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595.
REF 2 Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 2008 Nov 21;32(4):503-18.
REF 3 EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502.
REF 4 The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol. 1998 May;18(5):2825-34.
REF 5 Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol. 1998 Jun;18(6):3572-9.

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