Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T21123 Target Info
Target Name Hypoxia-inducible factor 2 alpha (HIF-2A)
Synonyms bHLHe73; PASD2; PAS domain-containing protein 2; Member of PAS protein 2; MOP2; Hypoxia-inducible factor 2-alpha; HLF; HIF2A; HIF2-alpha; HIF-2-alpha; HIF-1-alpha-like factor; Endothelial PAS domain-containing protein 1; EPAS-1; Class E basic helix-loop-helix protein 73; Basic-helix-loop-helix-PAS protein MOP2
Target Type Successful Target
Gene Name EPAS1
UniProt ID
EPAS1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Oxidoreductases [+] 3 Oxidoreductases +
Interacting Target Name HIF-prolyl hydroxylase 1 (HPH-1) Successful Target Interacting Protein Info
UniProt ID
EGLN2_HUMAN 
Synonyms Prolyl hydroxylase domain-containing protein 1; PHD1; Hypoxia-inducible factor prolyl hydroxylase 1; HPH-3; HIF-PH1; HIF-PH; Estrogen-induced tag6; Estrogen-induced tag 6; EIT-6; EIT6; Egl nine homolog 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [3]
Interacting Target Name HIF-prolyl hydroxylase 2 (HPH-2) Patented-recorded Target Interacting Protein Info
UniProt ID
EGLN1_HUMAN 
Synonyms SM-20; SM20; Prolyl hydroxylase domain-containing protein 2; Prolyl hydroxylase domaincontaining protein 2; PNAS-137; PNAS-118; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; Hypoxiainducible factor prolyl hydroxylase 2; HPH2; HIFprolyl hydroxylase 2; HIF-PH2; HIFPH2; Egl nine homolog 1; C1orf12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Interacting Protein Name Egl nine homolog 3 (EGLN3) Interacting Protein Interacting Protein Info
UniProt ID
EGLN3_HUMAN 
Synonyms HIFP4H3; HIFPH3; PHD3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [3]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Aryl hydrocarbon receptor nuclear translocator (ARNT) Interacting Protein Interacting Protein Info
UniProt ID
ARNT_HUMAN 
Synonyms HIF.1.beta; HIF.1beta; HIF1.beta; HIF1B; HIF1BETA; TANGO; bHLHe2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Co-crystal Structure [5]
4 Fluorescence Resonance Energy Transfer [6]
5 Reconstituted Complex [7]
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [8]
2 Yeast two hybrid [9]
Interacting Protein Name Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) Interacting Protein Interacting Protein Info
UniProt ID
ARNT2_HUMAN 
Synonyms WEDAS; bHLHe1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [10]
Other proteins [+] 2 Other proteins +
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-localization [12]
3 Fluorescence Resonance Energy Transfer [12]
4 Reconstituted Complex [11]
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-Western [13]
References  Top
REF 1 Identification of the hypoxia-inducible factor 2 nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. Mol Cell Proteomics. 2013 Mar;12(3):736-48.
REF 2 The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem. 2012 Aug 31;287(36):30800-11.
REF 3 The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol. 2007 May;27(10):3758-68.
REF 4 A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):654-9.
REF 5 Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-5.
REF 6 Molecular imaging: into in vivo interaction of HIF-1alpha and HIF-2alpha with ARNT. Ann N Y Acad Sci. 2009 Oct;1177:74-81.
REF 7 Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ Res. 2004 Jul 23;95(2):146-53.
REF 8 Opposite functions of HIF- isoforms in VEGF induction by TGF-1 under non-hypoxic conditions. Oncogene. 2011 Mar 10;30(10):1213-28.
REF 9 Functional proteomics mapping of a human signaling pathway. Genome Res. 2004 Jul;14(7):1324-32. Validation Studies
REF 10 An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 2010 Mar 5;140(5):744-52.
REF 11 Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator. J Biol Chem. 2005 Apr 8;280(14):14240-51.
REF 12 A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization. Oncogene. 2016 Jun 16;35(24):3125-38.
REF 13 Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2/androgen receptor signals. Oncotarget. 2015 Sep 29;6(29):27555-65.

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