Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T21653 Target Info
Target Name Omphalocele kinase 1 (NUAK1)
Synonyms OMPHK1; NUAK family SNF1-like kinase 1; KIAA0537; ARK5; AMPK-related protein kinase 5
Target Type Literature-reported Target
Gene Name NUAK1
Biochemical Class Kinase
UniProt ID
NUAK1_HUMAN 
Target Interacting Proteins  Top
Peptidases [+] 1 Peptidases +
Interacting Protein Name Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) Interacting Protein Interacting Protein Info
UniProt ID
USP9X_HUMAN 
Synonyms DFFRX; FAF; FAM; MRX99
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Other proteins [+] 2 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [1]
Interacting Protein Name F-box/WD repeat-containing protein 11 (FBXW11) Interacting Protein Interacting Protein Info
UniProt ID
FBW1B_HUMAN 
Synonyms BTRC2; BTRCP2; FBW1B; FBXW1B; Fbw11; Hos
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [1]
References  Top
REF 1 Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1MYPT1 phosphatase complex and the SCFTrCP E3 ubiquitin ligase. Biochem J. 2014 Jul 15;461(2):233-45.
REF 2 Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J. 2008 Apr 15;411(2):249-60.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.

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