Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T21960 Target Info
Target Name Angiopoietin-2 (ANGPT2)
Synonyms ANG-2
Target Type Successful Target
Gene Name ANGPT2
Biochemical Class Fibrinogen protein
UniProt ID
ANGP2_HUMAN 
Target Interacting Proteins  Top
Integrins [+] 2 Integrins +
Interacting Target Name Integrin alpha-5 (ITGA5) Clinical trial Target Interacting Protein Info
UniProt ID
ITA5_HUMAN 
Synonyms VLA-5; Integrin alpha-F; Integrin alpha-5 light chain; Integrin alpha-5 heavy chain; FNRA; Fibronectin receptor subunit alpha; CD49e antigen; CD49e; CD49 antigen-like family member E
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name Integrin beta-1 (ITGB1) Clinical trial Target Interacting Protein Info
UniProt ID
ITB1_HUMAN 
Synonyms VLA-4 subunit beta; MSK12; MDF2; Integrin VLA-4 beta subunit; GPIIA; Glycoprotein IIa; FNRB; Fibronectin receptor subunit beta; Fibronectin receptor beta subunit; CD29 antigen; CD29; Beta(1) integrin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Kinases [+] 1 Kinases +
Interacting Target Name Angiopoietin 1 receptor (TEK) Clinical trial Target Interacting Protein Info
UniProt ID
TIE2_HUMAN 
Synonyms VMCM1; VMCM; Tyrosine-protein kinase receptor TIE-2; Tyrosine-protein kinase receptor TEK; Tyrosine kinase with Ig and EGF homology domains-2; Tunica interna endothelial cell kinase; TIE2; P140 TEK; hTIE2; Endothelial tyrosine kinase; Endothelial Cell-Specific Receptor TIE-2; CD202b antigen; CD202b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [3]
References  Top
REF 1 Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 2006 Jan 15;66(2):775-83.
REF 2 Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with 51 integrin. J Biol Chem. 2014 Nov 7;289(45):31330-40.
REF 3 Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem. 2003 Jan 17;278(3):1721-7.

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