Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T22977 Target Info
Target Name Superoxide dismutase Cu-Zn (SOD Cu-Zn)
Synonyms hSod1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; Superoxide dismutase
Target Type Clinical trial Target
Gene Name SOD1
Biochemical Class Superoxide dismutase/reductase
UniProt ID
SODC_HUMAN 
Target Interacting Proteins  Top
Actins [+] 1 Actins +
Interacting Protein Name Destrin (DSTN) Interacting Protein Interacting Protein Info
UniProt ID
DEST_HUMAN 
Synonyms ACTDP; ADF; HEL32; bA462D18.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Aldehyde/ketonic transferases [+] 1 Aldehyde/ketonic transferases +
Interacting Target Name Transketolase (TK) Literature-reported Target Interacting Protein Info
UniProt ID
TKT_HUMAN 
Synonyms TKT1; SDDHD; HEL107; HEL-S-48
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Fluorescence Resonance Energy Transfer [4]
Interacting Protein Name TNF receptor associated protein 1 (TRAP1) Interacting Protein Interacting Protein Info
UniProt ID
TRAP1_HUMAN 
Synonyms HSP 75; HSP75; HSP90L; TRAP.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Isomerases [+] 1 Isomerases +
Interacting Target Name Rotamase A (PPIA) Successful Target Interacting Protein Info
UniProt ID
PPIA_HUMAN 
Synonyms PPIA; CyPA; Cyclophilin A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Kinases [+] 1 Kinases +
Interacting Protein Name ATP-AMP transphosphorylase 2 (AK2) Interacting Protein Interacting Protein Info
UniProt ID
KAD2_HUMAN 
Synonyms ADK2; AK 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Lyases [+] 1 Lyases +
Interacting Protein Name Beta-enolase (ENO3) Interacting Protein Interacting Protein Info
UniProt ID
ENOB_HUMAN 
Synonyms GSD13; MSE
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Protein Name Protein-beta-aspartate methyltransferase (PCMT1) Interacting Protein Interacting Protein Info
UniProt ID
PIMT_HUMAN 
Synonyms PIMT
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Oxidoreductases [+] 7 Oxidoreductases +
Interacting Protein Name Copper chaperone for superoxide dismutase (CCS) Interacting Protein Interacting Protein Info
UniProt ID
CCS_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Co-fractionation [2]
Interacting Target Name Thioredoxin reductase (PRDX5) Successful Target Interacting Protein Info
UniProt ID
PRDX5_HUMAN 
Synonyms TPx type VI; Thioredoxin peroxidase PMP20; SBBI10; Prx-V; PrxV; PLP; Peroxisomal antioxidant enzyme; Peroxiredoxin-5, mitochondrial; Peroxiredoxin5, mitochondrial; Peroxiredoxin V; Liver tissue 2D-page spot 71B; Liver tissue 2Dpage spot 71B; AOEB166; Antioxidant enzyme B166; Alu corepressor 1; ACR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Target Name Lactate dehydrogenase A (LDHA) Literature-reported Target Interacting Protein Info
UniProt ID
LDHA_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-59; Renal carcinoma antigen NYREN59; PIG19; L-lactate dehydrogenase A chain; Llactate dehydrogenase A chain; LDH-M; LDHM; LDH-A; LDH muscle subunit; Cell proliferation-inducing gene 19 protein; Cell proliferationinducing gene 19 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name L-lactate dehydrogenase A-like 6A (LDHAL6A) Interacting Protein Interacting Protein Info
UniProt ID
LDH6A_HUMAN 
Synonyms LDH6A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name L-lactate dehydrogenase B chain (LDHB) Interacting Protein Interacting Protein Info
UniProt ID
LDHB_HUMAN 
Synonyms HEL.S.281; LDH.B; LDH.H; LDHBD; TRG.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Malate dehydrogenase 2 (MDH2) Interacting Protein Interacting Protein Info
UniProt ID
MDHM_HUMAN 
Synonyms M.MDH; MDH; MGC:3559; MOR1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Peroxiredoxin-2 (PRDX2) Interacting Protein Interacting Protein Info
UniProt ID
PRDX2_HUMAN 
Synonyms HEL.S.2a; NKEF.B; NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Other proteins [+] 6 Other proteins +
Interacting Protein Name COMM domain-containing protein 1 (COMMD1) Interacting Protein Interacting Protein Info
UniProt ID
COMD1_HUMAN 
Synonyms C2orf5; MURR1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-localization [8]
3 Reconstituted Complex [8]
Interacting Target Name Mitochondrial 10kDa heat shock protein (HSPE1) Clinical trial Target Interacting Protein Info
UniProt ID
CH10_HUMAN 
Synonyms Hsp10; EPF; Early-pregnancy factor; Earlypregnancy factor; CPN10; Chaperonin 10; 10 kDa heat shock protein, mitochondrial; 10 kDa chaperonin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Target Name Transgelin-2 (TAGLN2) Literature-reported Target Interacting Protein Info
UniProt ID
TAGL2_HUMAN 
Synonyms SM22-alpha homolog; KIAA0120; Epididymis tissue protein Li 7e
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Polyadenylate-binding protein 4 (PABPC4) Interacting Protein Interacting Protein Info
UniProt ID
PABP4_HUMAN 
Synonyms APP.1; APP1; PABP4; iPABP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Programmed cell death 6-interacting protein (PDCD6IP) Interacting Protein Interacting Protein Info
UniProt ID
PDC6I_HUMAN 
Synonyms AIP1; ALIX; DRIP4; HP95
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Phosphatidylinositol transfer protein beta isoform (PITPNB) Interacting Protein Interacting Protein Info
UniProt ID
PIPNB_HUMAN 
Synonyms PI.TP.beta; PtdInsTP; VIB1B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
References  Top
REF 1 A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-B Signaling. Cell Syst. 2017 Dec 27;5(6):564-577.e12.
REF 2 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 3 Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes. Biochem Biophys Res Commun. 2004 Aug 27;321(3):574-83.
REF 4 Mutant SOD1 detoxification mechanisms in intact single cells. Cell Death Differ. 2008 Feb;15(2):312-21.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. Mol Cell Biol. 2010 Apr;30(8):1923-36.
REF 7 Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1. J Biol Chem. 2010 Sep 10;285(37):28991-9000.
REF 8 The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner. PLoS One. 2014 Apr 1;9(4):e92408.

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