Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T25464 Target Info
Target Name Calcineurin (PPP3CA)
Synonyms Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calmodulin-dependent calcineurin A subunit alpha isoform; CNA; CAM-PRP catalytic subunit; CALNA
Target Type Successful Target
Gene Name PPP3CA
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PP2BA_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Calcineurin subunit B type 1 (PPP3R1) Interacting Protein Interacting Protein Info
UniProt ID
CANB1_HUMAN 
Synonyms CALNB1; CNB; CNB1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Yeast two hybrid [4]
5 Yeast two hybrid [5]
6 Yeast two hybrid [6]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Protein-glutamate O-methyltransferase (ARMT1) Interacting Protein Interacting Protein Info
UniProt ID
ARMT1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [7]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Calcipressin-1 (RCAN1) Interacting Protein Interacting Protein Info
UniProt ID
RCAN1_HUMAN 
Synonyms ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [8]
References  Top
REF 1 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 4 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 5 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 6 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 7 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 8 Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin. PLoS One. 2012;7(10):e48315.

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