Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T26457 Target Info
Target Name Integrin beta-3 (ITGB3)
Synonyms GPIIIa; GP3A; CD61
Target Type Literature-reported Target
Gene Name ITGB3
Biochemical Class Integrin
UniProt ID
ITB3_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Integrin alpha-V (ITGAV) Clinical trial Target Interacting Protein Info
UniProt ID
ITAV_HUMAN 
Synonyms VTNR; VNRA; Vitronectin receptor subunit alpha; Vitronectin receptor alpha subunit; Vitronectin receptor; MSK8; CD51 antigen; CD51
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-crystal Structure [2]
3 Co-localization [3]
Integrins [+] 1 Integrins +
Interacting Target Name Integrin alpha-5 (ITGA5) Clinical trial Target Interacting Protein Info
UniProt ID
ITA5_HUMAN 
Synonyms VLA-5; Integrin alpha-F; Integrin alpha-5 light chain; Integrin alpha-5 heavy chain; FNRA; Fibronectin receptor subunit alpha; CD49e antigen; CD49e; CD49 antigen-like family member E
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [4]
2 Reconstituted Complex [5]
Kinases [+] 1 Kinases +
Interacting Target Name Focal adhesion kinase 1 (FAK) Clinical trial Target Interacting Protein Info
UniProt ID
FAK1_HUMAN 
Synonyms Protein-tyrosine kinase 2; Protein phosphatase 1 regulatory subunit 71; PPP1R71; pp125FAK; p125FAK; FRNK; Focal adhesion kinase-related nonkinase; FAK1; FADK 1; FADK
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Centromere protein R (ITGB3BP) Interacting Protein Interacting Protein Info
UniProt ID
CENPR_HUMAN 
Synonyms CENP.R; CENPR; HSU37139; NRIF3; TAP20
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [8]
2 Yeast two hybrid [9]
Other proteins [+] 2 Other proteins +
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Protein-peptide [11]
Interacting Protein Name Talin-1 (TLN1) Interacting Protein Interacting Protein Info
UniProt ID
TLN1_HUMAN 
Synonyms TLN; Talin-1; KIAA1027
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [12]
2 Reconstituted Complex [13]
References  Top
REF 1 A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen. Blood. 2000 Jul 1;96(1):161-9.
REF 2 Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 2002 Apr 5;296(5565):151-5.
REF 3 COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol. 2015 Mar;24(1):55-70.
REF 4 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 5 Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein. J Biol Chem. 1999 Jun 11;274(24):17257-66.
REF 6 Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. J Biol Chem. 1997 Jun 6;272(23):14740-6.
REF 7 Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol. 2002 Apr 1;157(1):149-60.
REF 8 Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. J Cell Biol. 1995 Nov;131(3):807-16.
REF 9 Novel alternatively spliced form of beta(3)-endonexin. Thromb Res. 2002 Jan 1;105(1):63-70.
REF 10 Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. J Biol Chem. 2010 Jan 1;285(1):30-42.
REF 11 Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding. J Biol Chem. 2000 Oct 6;275(40):30901-6.
REF 12 Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail. J Biol Chem. 1999 Oct 1;274(40):28575-83.
REF 13 The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem. 2002 Jun 14;277(24):21749-58.

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