Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T27918 Target Info
Target Name ATP-dependent RNA helicase DDX5 (DDX5)
Synonyms RNA helicase p68; Probable ATP-dependent RNA helicase DDX5; HLR1; HELR; G17P1; DEAD box protein 5
Target Type Clinical trial Target
Gene Name DDX5
UniProt ID
DDX5_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Probable ATP-dependent RNA helicase DDX17 (DDX17) Interacting Protein Interacting Protein Info
UniProt ID
DDX17_HUMAN 
Synonyms P72; RH70
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-fractionation [2]
3 Yeast two hybrid [3]
Interacting Protein Name ATP-dependent RNA helicase A (DHX9) Interacting Protein Interacting Protein Info
UniProt ID
DHX9_HUMAN 
Synonyms DDX9; LKP; NDH2; NDHII; RHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [4]
2 Yeast two hybrid [3]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Biochemical Activity [6]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [7]
3 Yeast two hybrid [8]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name Enhancer of zeste homolog 2 (EZH2) Successful Target Interacting Protein Info
UniProt ID
EZH2_HUMAN 
Synonyms Lysine N-methyltransferase 6; Lysine Nmethyltransferase 6; KMT6; Histone-lysine N-methyltransferase EZH2; Histonelysine Nmethyltransferase EZH2; EZH2 Y641N mutations; EZH2 Y641F mutations; ENX-1; ENX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
Other proteins [+] 3 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [11]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) Interacting Protein Interacting Protein Info
UniProt ID
HNRH1_HUMAN 
Synonyms HNRPH; HNRPH1; hnRNPH
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [4]
2 Yeast two hybrid [3]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) Interacting Protein Interacting Protein Info
UniProt ID
ROA0_HUMAN 
Synonyms HNRPA0
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [12]
2 Yeast two hybrid [3]
References  Top
REF 1 Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry. 2010 Jan 12;49(1):1-10.
REF 2 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 3 Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80.
REF 4 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 5 Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene. 2003 Jan 9;22(1):151-6.
REF 6 Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010 Oct 1;285(40):30443-52.
REF 7 Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Mol Cell Proteomics. 2010 Jun;9(6):1352-67.
REF 8 Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J Biol Chem. 2003 Jul 18;278(29):26704-14.
REF 9 The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127.
REF 10 RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis. Hepatology. 2016 Oct;64(4):1033-48.
REF 11 Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology. 2005 Oct;129(4):1225-36.
REF 12 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.

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