Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T29339 Target Info
Target Name Retinoic acid-inducible gene-1 (RIG-1)
Synonyms Retinoic acidinducible gene I protein; Retinoic acidinducible gene 1 protein; Retinoic acid-inducible gene I protein; Retinoic acid-inducible gene 1 protein; RLR1; RLR-1; RIGIlike receptor 1; RIGI; RIG1; RIG-I-like receptor 1; RIG-I; Probable ATPdependent RNA helicase DDX58; Probable ATP-dependent RNA helicase DDX58; DEAD box protein 58
Target Type Clinical trial Target
Gene Name DDX58
Biochemical Class Acid anhydride hydrolase
UniProt ID
DDX58_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name ATPase WRNIP1 (WRNIP1) Interacting Protein Interacting Protein Info
UniProt ID
WRIP1_HUMAN 
Synonyms WHIP; bA420G6.2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [1]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RNF135 (RNF135) Interacting Protein Interacting Protein Info
UniProt ID
RN135_HUMAN 
Synonyms MMFD; REUL; Riplet
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Yeast two hybrid [4]
5 Yeast two hybrid [5]
Ligases [+] 1 Ligases +
Interacting Protein Name E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25) Interacting Protein Interacting Protein Info
UniProt ID
TRI25_HUMAN 
Synonyms EFP; RNF147; Z147; ZNF147
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [9]
5 Affinity Capture-Western [10]
6 Affinity Capture-Western [11]
7 Affinity Capture-Western [3]
8 Affinity Capture-Western [4]
9 Affinity Capture-Western [12]
10 Affinity Capture-Western [13]
11 Co-localization [13]
12 Reconstituted Complex [14]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Mitochondrial antiviral-signaling protein (MAVS) Interacting Protein Interacting Protein Info
UniProt ID
MAVS_HUMAN 
Synonyms CARDIF; IPS.1; IPS1; VISA
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [15]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [16]
8 Affinity Capture-Western [17]
9 Affinity Capture-Western [18]
10 Affinity Capture-Western [19]
11 Affinity Capture-Western [10]
12 Affinity Capture-Western [20]
13 Affinity Capture-Western [11]
14 Affinity Capture-Western [21]
References  Top
REF 1 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 2 Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Mol Cell. 2017 Oct 19;68(2):293-307.e5.
REF 3 A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses. PLoS Pathog. 2013;9(8):e1003533.
REF 4 REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. PLoS One. 2009 Jun 1;4(6):e5760.
REF 5 Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. J Biol Chem. 2009 Jan 9;284(2):807-17.
REF 6 Phosphorylation-mediated negative regulation of RIG-I antiviral activity. J Virol. 2010 Apr;84(7):3220-9.
REF 7 Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production. J Biol Chem. 2010 Jun 25;285(26):20252-61.
REF 8 Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction. Mol Cell. 2011 Feb 4;41(3):354-65.
REF 9 Conventional protein kinase C- (PKC-) and PKC- negatively regulate RIG-I antiviral signal transduction. J Virol. 2012 Feb;86(3):1358-71.
REF 10 Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. Elife. 2017 Jun 8;6. pii: e24425.
REF 11 The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. Immunity. 2018 Sep 18;49(3):438-448.e5.
REF 12 Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. J Virol. 2016 Jun 24;90(14):6263-6275.
REF 13 The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. J Virol. 2017 Mar 29;91(8). pii: e02143-16.
REF 14 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007 Apr 19;446(7138):916-920. Letter;
REF 15 Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe. 2009 May 8;5(5):439-49.
REF 16 Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature. 2005 Oct 20;437(7062):1167-72.
REF 17 VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell. 2005 Sep 16;19(6):727-40.
REF 18 The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein. J Immunol. 2010 Jul 15;185(2):1158-68.
REF 19 Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms. Sci Rep. 2015 Jun 10;5:11220.
REF 20 The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling. J Virol. 2018 Feb 26;92(6). pii: e01737-17.
REF 21 FKBP8 inhibits virus-induced RLR-VISA signaling. J Med Virol. 2019 Mar;91(3):482-492.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.