Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T30829 Target Info
Target Name NIMA-related kinase 6 (NEK6)
Synonyms Serine/threonine-protein kinase Nek6; Protein kinase SID6-1512; NimA-related protein kinase 6; Never in mitosis A-related kinase 6
Target Type Literature-reported Target
Gene Name NEK6
Biochemical Class Kinase
UniProt ID
NEK6_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Protein Name Serine/threonine-protein kinase Nek9 (NEK9) Interacting Protein Interacting Protein Info
UniProt ID
NEK9_HUMAN 
Synonyms NERCC; NERCC1; Nek8
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Biochemical Activity [6]
7 Reconstituted Complex [6]
8 Yeast two hybrid [6]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 4 A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem. 2003 Sep 12;278(37):34897-909.
REF 5 Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev. 2002 Jul 1;16(13):1640-58.
REF 6 Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J Proteome Res. 2010 Dec 3;9(12):6298-316.

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