Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T31621 Target Info
Target Name Fibroblast growth factor-2 (FGF2)
Synonyms bFGF; Heparin-binding growth factor 2; HBGF-2; Fibroblast growth factor 2; FGFB; FGF-2; Basic fibroblast growth factor
Target Type Successful Target
Gene Name FGF2
Biochemical Class Growth factor
UniProt ID
FGF2_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target Interacting Protein Info
UniProt ID
FGFR1_HUMAN 
Synonyms N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-fractionation [4]
6 Reconstituted Complex [4]
7 Reconstituted Complex [1]
8 Reconstituted Complex [5]
9 Reconstituted Complex [6]
Interacting Target Name Fibroblast growth factor receptor 2 (FGFR2) Successful Target Interacting Protein Info
UniProt ID
FGFR2_HUMAN 
Synonyms K-sam; KSAM; KGFR; Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; FGFR-2; FGF-2 receptor; CD332; BEK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Protein-peptide [8]
3 Reconstituted Complex [9]
References  Top
REF 1 Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican. J Cell Biol. 1996 Apr;133(2):405-16.
REF 2 Nuclear accumulation of fibroblast growth factor receptors in human glial cells--association with cell proliferation. Oncogene. 1997 May 8;14(18):2201-11.
REF 3 S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner. J Cell Sci. 2011 Jul 15;124(Pt 14):2389-400.
REF 4 Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization. Biochemistry. 1994 Aug 30;33(34):10229-48.
REF 5 Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly. Biochemistry. 2004 Apr 27;43(16):4724-30.
REF 6 Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 receptor binding in breast carcinomas. Am J Pathol. 2002 Jan;160(1):185-94.
REF 7 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 8 Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor. J Neurochem. 2008 Feb;104(3):667-82.
REF 9 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J. 1990 Sep;9(9):2685-92.

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