Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T33455 | Target Info | |||
Target Name | Insulin-like growth factor-binding protein 3 (IGFBP3) | ||||
Synonyms | IGFBP-3; IGF-binding protein 3; IBP3; IBP-3 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | IGFBP3 | ||||
Biochemical Class | Insulin-like growth factor binding | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Other proteins | [+] 2 Other proteins | + | |||
Interacting Target Name | Fibronectin (FN1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Ugl-Y3; Ugl-Y2; Ugl-Y1; FN; Cold-insoluble globulin; CIG | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Reconstituted Complex | [2] | |||
3 | Reconstituted Complex | [1] | |||
4 | Yeast two hybrid | [1] | |||
Interacting Target Name | Insulin-like growth factor-I (IGF1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Somatomedin-C; SomatomedinC; Mechano growth factor; Insulin-like growth factor I; IGF-I; IGFI | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [3] | |||
2 | Affinity Capture-Western | [4] | |||
3 | Reconstituted Complex | [3] | |||
4 | Reconstituted Complex | [5] |
References | Top | ||||
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REF 1 | Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma. J Clin Endocrinol Metab. 2001 May;86(5):2104-10. | ||||
REF 2 | Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage. Osteoarthritis Cartilage. 2002 Jul;10(7):556-63. | ||||
REF 3 | Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding. J Clin Endocrinol Metab. 2001 Oct;86(10):4943-50. | ||||
REF 4 | Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct;75(4):1046-53. | ||||
REF 5 | Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. J Biol Chem. 1998 Jan 30;273(5):2631-8. |
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