Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T35173 | Target Info | |||
Target Name | Cellular inhibitor of apoptosis 2 (BIRC3) | ||||
Synonyms | hIAP1; hIAP-1; TNFR2TRAFsignaling complex protein 1; TNFR2-TRAF-signaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; CIAP2; C-IAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | BIRC3 | ||||
Biochemical Class | Acyltransferase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Acyltransferases | [+] 3 Acyltransferases | + | |||
Interacting Protein Name | TNF receptor-associated factor 2 (TRAF2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MGC:45012; TRAP; TRAP3 | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Biochemical Activity | [3] | |||
4 | Co-localization | [4] | |||
5 | Reconstituted Complex | [2] | |||
6 | Yeast two hybrid | [5] | |||
Interacting Target Name | TNF receptor-associated factor 6 (TRAF6) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [6] | |||
Interacting Protein Name | TNF receptor-associated factor 3 (TRAF3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CAP.1; CAP1; CD40bp; CRAF1; IIAE5; LAP1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Biochemical Activity | [7] | |||
Adapter proteins | [+] 1 Adapter proteins | + | |||
Interacting Protein Name | TNF receptor-associated factor 1 (TRAF1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | EBI6; MGC:10353 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Co-localization | [4] | |||
3 | Reconstituted Complex | [8] | |||
Kinases | [+] 2 Kinases | + | |||
Interacting Target Name | Receptor-interacting protein 1 (RIPK1) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [9] | |||
2 | Biochemical Activity | [9] | |||
3 | Reconstituted Complex | [9] | |||
Interacting Protein Name | Receptor-interacting protein 2 (RIP2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | UNQ277/PRO314/PRO34092; Tyrosine-protein kinase RIPK2; RIP-like-interacting CLARP kinase; RIP-2; RIP2; RICK; Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting protein 2; CARDIAK; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [10] | |||
2 | Biochemical Activity | [9] | |||
3 | Reconstituted Complex | [11] | |||
Peptidases | [+] 3 Peptidases | + | |||
Interacting Target Name | Caspase-9 (CASP9) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [12] | |||
2 | Co-localization | [4] | |||
3 | Reconstituted Complex | [12] | |||
4 | Yeast two hybrid | [13] | |||
Interacting Target Name | Caspase-3 (CASP3) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [14] | |||
2 | Reconstituted Complex | [15] | |||
Interacting Target Name | Caspase-7 (CASP7) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [16] | |||
2 | Reconstituted Complex | [15] | |||
Ubiquitin related proteins | [+] 4 Ubiquitin related proteins | + | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [17] | |||
2 | Co-crystal Structure | [18] | |||
3 | Reconstituted Complex | [18] | |||
4 | Yeast two hybrid | [19] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [17] | |||
2 | Reconstituted Complex | [9] | |||
3 | Yeast two hybrid | [19] | |||
Interacting Protein Name | Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | E2(17)KB3; UBC4/5; UBCH5C | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [17] | |||
2 | Reconstituted Complex | [20] | |||
3 | Yeast two hybrid | [19] | |||
Interacting Target Name | Polyubiquitin-C (UBC) | Patented-recorded Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | HMG20; ubiquitin C | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Biochemical Activity | [21] | |||
2 | Reconstituted Complex | [22] | |||
Other proteins | [+] 3 Other proteins | + | |||
Interacting Target Name | Direct IAP-binding protein with low pI (DIABLO) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [17] | |||
2 | Biochemical Activity | [23] | |||
3 | Reconstituted Complex | [24] | |||
Interacting Protein Name | B-cell lymphoma/leukemia 10 (BCL10) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CARMEN; CIPER; CLAP; IMD37; c.E10; mE10 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [25] | |||
2 | Biochemical Activity | [26] | |||
Interacting Protein Name | NF-kappa-B essential modulator (IKBKG) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Reconstituted Complex | [22] |
References | Top | ||||
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REF 1 | OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J. 2013 Apr 17;32(8):1103-14. | ||||
REF 2 | Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell. 2010 Apr 9;38(1):101-13. | ||||
REF 3 | IB kinase phosphorylates TRAF2 to promote mammary epithelial cell transformation. Mol Cell Biol. 2012 Dec;32(23):4756-68. | ||||
REF 4 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
REF 5 | Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-assoc... Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8. | ||||
REF 6 | K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5. Nat Immunol. 2014 Mar;15(3):231-8. | ||||
REF 7 | Noncanonical NF-B activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif. Sci Signal. 2013 Apr 23;6(272):ra27. | ||||
REF 8 | TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 2002 Mar 21;416(6878):345-7. | ||||
REF 9 | cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356. | ||||
REF 10 | Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol. 1998 Jul 16;8(15):885-8. | ||||
REF 11 | Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity. 2009 Jun 19;30(6):789-801. | ||||
REF 12 | IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23. | ||||
REF 13 | Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536. | ||||
REF 14 | IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct;2(10):e114. | ||||
REF 15 | The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 1;16(23):6914-25. | ||||
REF 16 | The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10;281(6):3254-60. | ||||
REF 17 | Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. J Biol Chem. 2003 Mar 21;278(12):10055-60. | ||||
REF 18 | Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. J Biol Chem. 2008 Nov 14;283(46):31633-40. | ||||
REF 19 | c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209. | ||||
REF 20 | Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ. 2011 Aug;18(8):1376-86. | ||||
REF 21 | Gliotoxin suppresses NF-B activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem Biol. 2015 Mar 20;10(3):675-81. | ||||
REF 22 | IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol. 2008 Nov;10(11):1309-17. | ||||
REF 23 | The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem. 2014 Sep 12;289(37):25721-36. | ||||
REF 24 | Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J Biol Chem. 2004 Apr 23;279(17):16963-70. | ||||
REF 25 | CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation. Cell Cycle. 2006 Jul;5(13):1438-42. | ||||
REF 26 | cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest. 2006 Jan;116(1):174-81. |
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