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| Target General Information |
Top |
| Target ID |
T38996 |
Target Info
|
| Target Name |
Phospholipase D1 (PLD1) |
| Synonyms |
Phosphatidylcholine-hydrolyzing phospholipase D1; PLD 1; HPLD1; Choline phosphatase 1 |
| Target Type |
Patented-recorded Target |
| Gene Name |
PLD1 |
| Biochemical Class |
Phosphoric diester hydrolase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Acid anhydride hydrolases |
[+] 2 Acid anhydride hydrolases |
+ |
| Interacting Target Name |
Transforming protein RhoA (RHOA) |
Discontinued Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Transforming protein RhoA; RHO12; Rho cDNA clone 12; h12; ARHA; ARH12 |
| Evidence Score (E-score) |
5 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| 3 |
Protein-peptide |
[1] |
| 4 |
Reconstituted Complex |
[2] |
| 5 |
Reconstituted Complex |
[1] |
| Interacting Target Name |
ADP-ribosylation factor 1 (ARF1) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
PVNH8 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[3] |
| 2 |
Co-fractionation |
[4] |
| References |
Top |
| REF 1 |
Determination of interaction sites of phospholipase D1 for RhoA. Biochem J. 2001 May 1;355(Pt 3):779-85.
|
| REF 2 |
Activation of phospholipase D1 by ADP-ribosylated RhoA. Biochem Biophys Res Commun. 2003 Feb 28;302(1):127-32.
|
| REF 3 |
Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA. FEBS Lett. 1998 Jul 3;430(3):231-5.
|
| REF 4 |
Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
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