Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39321 | Target Info | |||
| Target Name | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | ||||
| Synonyms | Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GAPDH | ||||
| Biochemical Class | Aldehyde/oxo donor oxidoreductase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Heat shock proteins | [+] 1 Heat shock proteins | + | |||
| Interacting Target Name | Heat shock protein 90 alpha (HSP90A) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Co-fractionation | [2] | |||
| Kinases | [+] 2 Kinases | + | |||
| Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-Western | [3] | |||
| 3 | Protein-Fragment Complementation Assay | [4] | |||
| 4 | Yeast two hybrid | [5] | |||
| Interacting Protein Name | Phosphoglycerate kinase 1 (PGK1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HEL.S.68p; MIG10; PGKA | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Co-fractionation | [7] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Target Name | Synuclein alpha (SNCA) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [8] | |||
| 2 | Yeast two hybrid | [9] | |||
| Interacting Target Name | Nucleophosmin (NPM1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [10] | |||
| 2 | Affinity Capture-Western | [11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A proteomic snapshot of the human heat shock protein 90 interactome. FEBS Lett. 2005 Nov 21;579(28):6350-4. | ||||
| REF 2 | Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44. | ||||
| REF 3 | Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation ... Mol Cell Proteomics. 2006 Sep;5(9):1610-27. | ||||
| REF 4 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
| REF 5 | In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84. | ||||
| REF 6 | A study on the complexes between human erythrocyte enzymes participating in the conversions of 1,3-diphosphoglycerate. Arch Biochem Biophys. 1997 Sep 15;345(2):185-92. | ||||
| REF 7 | A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81. | ||||
| REF 8 | Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions. Eur J Neurosci. 2005 Jan;21(2):317-26. | ||||
| REF 9 | A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8. | ||||
| REF 10 | Quantitative study of the interactome of PKC involved in the EGF-induced tumor cell chemotaxis. J Proteome Res. 2013 Mar 1;12(3):1478-86. | ||||
| REF 11 | S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade. J Cell Biol. 2012 Oct 1;199(1):65-76. | ||||
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