Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T42890 Target Info
Target Name Enhancer of filamentation 1 (NEDD9)
Synonyms p105; hEF1; Renal carcinoma antigen NY-REN-12; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; CasL; Cas scaffolding protein family member 2; CRK-associated substrate-related protein; CASS2; CAS-L
Target Type Literature-reported Target
Gene Name NEDD9
UniProt ID
CASL_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Interacting Protein Info
UniProt ID
SMAD3_HUMAN 
Synonyms TGF-beta response effector Smad3; Smad3; SMAD family member 3; SMAD 3; Mothers against DPP homolog 3; MMad3; MADH3; Mad3; MAD homolog 3; JV15-2; HSMAD3; HMAD-3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [1]
Interacting Protein Name Mad-related protein 1 (SMAD1) Interacting Protein Interacting Protein Info
UniProt ID
SMAD1_HUMAN 
Synonyms Transforming growth factor-beta-signaling protein 1; Smad1; SMAD family member 1; SMAD 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; Mad-related protein 1; MADR1; MADH1; MAD homolog 1; JV4-1; BSP-1; BSP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [3]
Other proteins [+] 1 Other proteins +
Interacting Target Name Proto-oncogene c-Crk (c-Crk) Literature-reported Target Interacting Protein Info
UniProt ID
CRK_HUMAN 
Synonyms P38; Adapter molecule crk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [4]
References  Top
REF 1 A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1. EMBO J. 2000 Dec 15;19(24):6759-69.
REF 2 Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. BMC Cell Biol. 2004 May 16;5:20.
REF 3 Functional proteomics mapping of a human signaling pathway. Genome Res. 2004 Jul;14(7):1324-32. Validation Studies
REF 4 T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. J Biol Chem. 1998 Mar 13;273(11):6446-51.

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