Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T43115 Target Info
Target Name Leukocyte common antigen (PTPRC)
Synonyms T200; Receptor-type tyrosine-protein phosphatase C; L-CA; CD45 antigen; CD45
Target Type Clinical trial Target
Gene Name PTPRC
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTPRC_HUMAN 
Target Interacting Proteins  Top
Glycosylases [+] 1 Glycosylases +
Interacting Protein Name Neutral alpha-glucosidase AB (GANAB) Interacting Protein Interacting Protein Info
UniProt ID
GANAB_HUMAN 
Synonyms G2AN; GLUII
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [1]
5 Reconstituted Complex [3]
Kinases [+] 1 Kinases +
Interacting Target Name LCK tyrosine protein kinase (LCK) Successful Target Interacting Protein Info
UniProt ID
LCK_HUMAN 
Synonyms Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; Leukocyte C-terminal Src kinase; LCK Protooncogene Syn; LCK p59-Fyn
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Reconstituted Complex [5]
References  Top
REF 1 Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II. J Biol Chem. 1997 May 16;272(20):13117-25.
REF 2 Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction. J Biol Chem. 2000 Oct 13;275(41):32071-6.
REF 3 Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45. J Immunol. 2001 Oct 1;167(7):3829-35.
REF 4 CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line. J Biol Chem. 1993 Apr 25;268(12):8958-64.
REF 5 Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro. J Biol Chem. 1996 Jan 19;271(3):1295-300.

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