Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44861 | Target Info | |||
| Target Name | Protein kinase C delta (PRKCD) | ||||
| Synonyms | nPKC-delta; Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; PKC-delta | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PRKCD | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Transcription regulators | [+] 2 Transcription regulators | + | |||
| Interacting Target Name | Transcription factor Sp1 (SP1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TSFP1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Protein-peptide | [2] | |||
| Interacting Target Name | Signal transducer and activator of transcription 1 (STAT1) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Biochemical Activity | [4] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Target Name | von Hippel-Lindau disease tumor suppressor (VHL) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | pVHL; Protein G7 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Fluorescence Resonance Energy Transfer | [6] | |||
| Interacting Target Name | Insulin receptor substrate-1 (IRS1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | IRS-1; Insulin receptor substrate 1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Biochemical Activity | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer J Biochem. 2012 Jun;151(6):599-610. | ||||
| REF 2 | Interplay between PKC and Sp1 on histone deacetylase inhibitor-mediated Epstein-Barr virus reactivation. J Virol. 2011 Mar;85(5):2373-85. | ||||
| REF 3 | Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J Biol Chem. 2003 Sep 5;278(36):33637-44. | ||||
| REF 4 | Activation of protein kinase C delta by IFN-gamma. J Immunol. 2003 Jul 1;171(1):267-73. | ||||
| REF 5 | Von Hippel-Lindau regulates interleukin-32 stability in ovarian cancer cells. Oncotarget. 2017 Jul 17;8(41):69833-69846. | ||||
| REF 6 | The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta. Biochem J. 2006 Jul 1;397(1):109-20. | ||||
| REF 7 | Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling. Diabetes. 2002 Jun;51(6):1921-30. | ||||
| REF 8 | Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism. Oncogene. 2004 Dec 9;23(57):9269-79. | ||||
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