Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44916 | Target Info | |||
| Target Name | Embryonic ectoderm development protein (EED) | ||||
| Synonyms | hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | EED | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Carbon-nitrogen hydrolases | [+] 1 Carbon-nitrogen hydrolases | + | |||
| Interacting Target Name | Histone deacetylase 1 (HDAC1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RPD3L1; HD1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| One-carbon transferases | [+] 2 One-carbon transferases | + | |||
| Interacting Target Name | Enhancer of zeste homolog 2 (EZH2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Lysine N-methyltransferase 6; Lysine Nmethyltransferase 6; KMT6; Histone-lysine N-methyltransferase EZH2; Histonelysine Nmethyltransferase EZH2; EZH2 Y641N mutations; EZH2 Y641F mutations; ENX-1; ENX1 | ||||
| Evidence Score (E-score) | 6 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [3] | |||
| 3 | Biochemical Activity | [4] | |||
| 4 | Co-localization | [5] | |||
| 5 | Reconstituted Complex | [4] | |||
| 6 | Yeast two hybrid | [6] | |||
| Interacting Target Name | Enhancer of zeste homolog 1 (EZH1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | KIAA0388; Histone-lysine N-methyltransferase EZH1; ENX-2 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Affinity Capture-Western | [8] | |||
| 3 | Reconstituted Complex | [9] | |||
| 4 | Yeast two hybrid | [6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
| REF 2 | Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet. 1999 Dec;23(4):474-8. | ||||
| REF 3 | JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. 2010 Mar 11;464(7286):306-10. | ||||
| REF 4 | Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev. 2010 Dec 1;24(23):2615-20. | ||||
| REF 5 | The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127. | ||||
| REF 6 | Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol. 1998 Jun;18(6):3572-9. | ||||
| REF 7 | A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. | ||||
| REF 8 | Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 2008 Nov 21;32(4):503-18. | ||||
| REF 9 | The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. Mol Cell Biol. 1998 May;18(5):2825-34. | ||||
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