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| Target General Information |
Top |
| Target ID |
T46515 |
Target Info
|
| Target Name |
Isoleucyl-tRNA synthetase (IARS) |
| Synonyms |
Isoleucine--tRNA ligase, cytoplasmic; Isoleucine--tRNA ligase; IleRS; IRS |
| Target Type |
Literature-reported Target |
| Gene Name |
IARS |
| Biochemical Class |
Carbon-oxygen ligase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Epidermal growth factor receptor (EGFR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III |
| Evidence Score (E-score) |
1 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| Ligases |
[+] 1 Ligases |
+ |
| Interacting Target Name |
Bifunctional aminoacyl-tRNA synthetase (EPRS) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
QPRS; QARS; ProlinetRNA ligase; PIG32; Glutamatyl-prolyl-tRNA synthetase; GlutamatylprolyltRNA synthetase; GluRS; EPRS; Cell proliferation-inducing gene 32 protein; Cell proliferationinducing gene 32 protein; Bifunctional glutamate/proline--tRNA ligase; Bifunctional glutamate/prolinetRNA ligase; Bifunctional aminoacyl-tRNA synthetase; Bifunctional aminoacyltRNA synthetase |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[2] |
| 2 |
Co-fractionation |
[3] |
| 3 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul;13(7):1644-58.
|
| REF 2 |
A multifunctional repeated motif is present in human bifunctional tRNA synthetase. J Biol Chem. 1998 May 1;273(18):11267-73.
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| REF 3 |
Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
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