Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T46541 Target Info
Target Name Borealin (CDCA8)
Synonyms hDasraB; hDasra-B; Pluripotent embryonic stem cellrelated gene 3 protein; Pluripotent embryonic stem cell-related gene 3 protein; PESCRG3; DasraB; Dasra-B; Dasra B; Cell division cycleassociated protein 8; Cell division cycle-associated protein 8
Target Type Literature-reported Target
Gene Name CDCA8
UniProt ID
BOREA_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name Aurora kinase B (AURKB) Clinical trial Target Interacting Protein Info
UniProt ID
AURKB_HUMAN 
Synonyms STK5; STK12; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora/IPL1-related kinase 2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK-2; ARK2; AIRK2; AIM-1; AIM1; AIK2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Co-localization [7]
Other proteins [+] 2 Other proteins +
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
7 Affinity Capture-Western [6]
8 Reconstituted Complex [2]
9 Reconstituted Complex [9]
10 Reconstituted Complex [4]
11 Yeast two hybrid [4]
12 Yeast two hybrid [10]
Interacting Protein Name Inner centromere protein (INCENP) Interacting Protein Interacting Protein Info
UniProt ID
INCE_HUMAN 
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [6]
5 Reconstituted Complex [2]
6 Reconstituted Complex [10]
7 Yeast two hybrid [4]
8 Yeast two hybrid [10]
References  Top
REF 1 The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell. 2004 Jul 23;118(2):187-202.
REF 2 Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004 Jul 19;166(2):179-91.
REF 3 The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006 Dec;7(12):1259-65.
REF 4 Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007 Oct 19;131(2):271-85.
REF 5 Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46.
REF 6 RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Mol Biol Cell. 2009 Jan;20(1):410-8.
REF 7 INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53.
REF 8 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 9 Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. J Biol Chem. 2006 Jan 13;281(2):1286-95.
REF 10 Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell. 2006 Jun;17(6):2547-58.

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