Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T48040 Target Info
Target Name DNA repair protein complementing XP-A cells (XPA)
Synonyms Xeroderma pigmentosum group A-complementing protein; XPAC; XPA protein
Target Type Literature-reported Target
Gene Name XPA
UniProt ID
XPA_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 3 Other proteins +
Interacting Protein Name DNA excision repair protein ERCC-1 (ERCC1) Interacting Protein Interacting Protein Info
UniProt ID
ERCC1_HUMAN 
Synonyms COFS4; RAD10; UV20
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [3]
Interacting Protein Name Replication factor A protein 1 (RPA1) Interacting Protein Interacting Protein Info
UniProt ID
RFA1_HUMAN 
Synonyms HSSB; MST075; REPA1; RF.A; RP.A; RPA70
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [6]
3 Yeast two hybrid [6]
Interacting Protein Name Replication protein A 32 kDa subunit (RPA2) Interacting Protein Interacting Protein Info
UniProt ID
RFA2_HUMAN 
Synonyms REPA2; RP.A p32; RP.A p34; RPA32
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [8]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 Specific association between the human DNA repair proteins XPA and ERCC1. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5012-6.
REF 4 Physical and functional interaction between DDB and XPA in nucleotide excision repair. Nucleic Acids Res. 2009 Feb;37(2):516-25.
REF 5 Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks. DNA Repair (Amst). 2009 Jul 4;8(7):865-72.
REF 6 An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair. Mol Cell Biol. 1995 Oct;15(10):5396-402.
REF 7 SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell. 2010 Jul 30;39(2):247-58.
REF 8 Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. Cell. 2000 Oct 27;103(3):449-56.

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