Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T49526 Target Info
Target Name Voltage-gated potassium channel Kv7.1 (KCNQ1)
Synonyms Voltage-gated potassium channel subunit Kv7.1; Potassium voltage-gated channel subfamily KQT member 1; Kv7.1; KVLQT1; KQT-like 1; KCNQ1 channel; KCNA9; KCNA8; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1
Target Type Successful Target
Gene Name KCNQ1
Biochemical Class Voltage-gated ion channel
UniProt ID
KCNQ1_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Protein Name Potassium voltage-gated channel subfamily E member 1 (KCNE1) Interacting Protein Interacting Protein Info
UniProt ID
KCNE1_HUMAN 
Synonyms ISK; JLNS; JLNS2; LQT2/5; LQT5; MinK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Other proteins [+] 1 Other proteins +
Interacting Protein Name A-kinase anchor protein 9 (AKAP9) Interacting Protein Interacting Protein Info
UniProt ID
AKAP9_HUMAN 
Synonyms AKAP.9; AKAP350; AKAP450; CG.NAP; HYPERION; LQT11; MU.RMS.40.16A; PPP1R45; PRKA9; YOTIAO
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [4]
References  Top
REF 1 LQT1-associated mutations increase KCNQ1 proteasomal degradation independently of Derlin-1. J Biol Chem. 2009 Feb 20;284(8):5250-6.
REF 2 A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction. J Mol Cell Cardiol. 2014 Jul;72:273-80.
REF 3 KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 2000 Dec 1;19(23):6326-30.
REF 4 Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science. 2002 Jan 18;295(5554):496-9.
REF 5 Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20990-5.

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