Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49755 | Target Info | |||
| Target Name | LDL receptor related protein-6 (LRP-6) | ||||
| Synonyms | Low-density lipoprotein receptor-related protein 6 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | LRP6 | ||||
| Biochemical Class | Low density lipoprotein receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Serine/threonine-protein kinase GSK3B; GSK-3 beta | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Far Western | [2] | |||
| Other proteins | [+] 3 Other proteins | + | |||
| Interacting Protein Name | Axin-1 (AXIN1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | AXIN; PPP1R49 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [3] | |||
| 3 | Far Western | [2] | |||
| Interacting Target Name | Dickkopf-related protein 1 (DKK1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | UNQ492/PRO1008; SK; hDkk-1; hDkk1; Dkk-1; Dkk1; Dickkopfrelated protein 1; Dickkopf-1; Dickkopf1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-localization | [4] | |||
| 2 | Reconstituted Complex | [5] | |||
| Interacting Target Name | Sclerostin (SOST) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | UNQ2976/PRO7455/PRO7476 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Affinity Capture-Western | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell. 2006 Aug;11(2):213-23. | ||||
| REF 2 | Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS One. 2008;3(12):e4046. | ||||
| REF 3 | Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase. Genes Cancer. 2017 Jul;8(7-8):613-627. | ||||
| REF 4 | Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell. 2004 Mar 19;116(6):883-95. | ||||
| REF 5 | Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol. 2001 Jun 26;11(12):951-61. | ||||
| REF 6 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 7 | SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem. 2005 Jul 22;280(29):26770-5. | ||||
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