Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T50942 Target Info
Target Name Low-affinity nerve growth factor receptor (NGFR)
Synonyms p75 ICD; Tumor necrosis factor receptor superfamily member 16; TNFRSF16; P75neurotrophin receptor (p75(NTR)); P75NTR; P75ICD; NGFreceptor; NGF-P75 receptor; NGF receptor; Lowaffinity neurotrophin receptor p75NTR; Low affinity neurotrophin receptor p75NTR; Gp80-LNGFR; CD271; 75kD-neurotrophin receptor
Target Type Successful Target
Gene Name NGFR
Biochemical Class Cytokine receptor
UniProt ID
TNR16_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [2]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name Protein BEX3 (BEX3) Interacting Protein Interacting Protein Info
UniProt ID
BEX3_HUMAN 
Synonyms BEX3; Bex; DXS6984E; HGR74; NADE
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [4]
Interacting Protein Name TNF receptor-associated factor 4 (TRAF4) Interacting Protein Interacting Protein Info
UniProt ID
TRAF4_HUMAN 
Synonyms CART1; MLN62; RNF83
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Reconstituted Complex [6]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Necdin (NDN) Interacting Protein Interacting Protein Info
UniProt ID
NECD_HUMAN 
Synonyms HsT16328; PWCR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [9]
References  Top
REF 1 TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J Biol Chem. 1999 Oct 15;274(42):30202-8.
REF 2 A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF. J Biol Chem. 2004 Apr 16;279(16):16646-56.
REF 3 TRAF6 and p62 inhibit amyloid -induced neuronal death through p75 neurotrophin receptor. Neurochem Int. 2012 Dec;61(8):1289-93.
REF 4 NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000 Jun 9;275(23):17566-70.
REF 5 The TSC1 gene product hamartin interacts with NADE. Mol Cell Neurosci. 2007 May;35(1):100-8.
REF 6 TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am J Pathol. 1998 Jun;152(6):1549-61.
REF 7 Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. J Neurosci. 2003 Apr 15;23(8):3209-20.
REF 8 The p75 neurotrophin receptor interacts with multiple MAGE proteins. J Biol Chem. 2002 Dec 20;277(51):49101-4.
REF 9 Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J Biol Chem. 2004 Jan 16;279(3):1703-12.

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