Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T51817 Target Info
Target Name GATA-binding factor 4 (GATA4)
Synonyms Transcription factor GATA-4; GATA-4; GATA binding factor-4
Target Type Literature-reported Target
Gene Name GATA4
Biochemical Class Zinc-finger
UniProt ID
GATA4_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Homeobox protein Nkx-2.5 (NKX2-5) Interacting Protein Interacting Protein Info
UniProt ID
NKX25_HUMAN 
Synonyms CHNG5; CSX; CSX1; HLHS2; NKX2.5; NKX2E; NKX4.1; VSD3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [2]
Interacting Protein Name Zinc finger protein ZFPM2 (ZFPM2) Interacting Protein Interacting Protein Info
UniProt ID
FOG2_HUMAN 
Synonyms DIH3; FOG2; SRXY9; ZC2HC11B; ZNF89B; hFOG.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
3 Reconstituted Complex [6]
4 Yeast two hybrid [5]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Protein Jumonji (JARID2) Interacting Protein Interacting Protein Info
UniProt ID
JARD2_HUMAN 
Synonyms JMJ
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [4]
References  Top
REF 1 GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature. 2003 Jul 24;424(6947):443-7.
REF 2 Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. J Biol Chem. 2000 Nov 10;275(45):35291-6.
REF 3 The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 1997 Sep 15;16(18):5687-96.
REF 4 Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004 Dec;24(23):10151-60.
REF 5 Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):956-61.
REF 6 A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. J Biol Chem. 2000 Jul 7;275(27):20762-9.
REF 7 PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012 Jan 1;26(1):37-42.

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