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| Target General Information |
Top |
| Target ID |
T52389 |
Target Info
|
| Target Name |
Quinone reductase 1 (NQO1) |
| Synonyms |
Qui reductase 1; QR1; Phylloquinone reductase; Phylloqui reductase; NMOR1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H dehydrogenase [quinone] 1; Menadione reductase; DTD; DT-diaphorase 1; DT-diaphorase; DIA4; Azoreductase |
| Target Type |
Clinical trial Target |
| Gene Name |
NQO1 |
| Biochemical Class |
NADH/NADPH oxidoreductase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Transcription regulators |
[+] 1 Transcription regulators |
+ |
| Interacting Target Name |
Hypoxia-inducible factor 1 alpha (HIF-1A) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 Jun 28;16(1):37-47.
|
| REF 2 |
NQO1 inhibits proteasome-mediated degradation of HIF-1. Nat Commun. 2016 Dec 14;7:13593.
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