Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T55959 Target Info
Target Name Dopamine transporter (DAT)
Synonyms Solute carrier family 6 member 3; Sodium-dependent dopamine transporter; DAT1; DAT; DA transporter
Target Type Successful Target
Gene Name SLC6A3
Biochemical Class Neurotransmitter:sodium symporter
UniProt ID
SC6A3_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 1 Other proteins +
Interacting Target Name Synuclein alpha (SNCA) Clinical trial Target Interacting Protein Info
UniProt ID
SYUA_HUMAN 
Synonyms PARK1; Non-A4 component of amyloid precursor; NonA4 component of amyloid precursor; Non-A beta component of AD amyloid; NonA beta component of AD amyloid; NACP
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Yeast two hybrid [2]
References  Top
REF 1 Attenuation of dopamine transporter activity by alpha-synuclein. Neurosci Lett. 2003 Apr 17;340(3):189-92.
REF 2 Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J. 2001 Apr;15(6):916-26.
REF 3 Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity. Mol Cell Neurosci. 2003 Sep;24(1):91-105.
REF 4 Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant. Biochemistry. 2004 Feb 10;43(5):1242-53.
REF 5 Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter. Biochemistry. 2005 Oct 18;44(41):13612-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.