Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T56418 Target Info
Target Name ALK tyrosine kinase receptor (ALK)
Synonyms CD246; Anaplastic lymphoma kinase
Target Type Successful Target
Gene Name ALK
Biochemical Class Kinase
UniProt ID
ALK_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [3]
Kinases [+] 1 Kinases +
Interacting Target Name Janus kinase 3 (JAK-3) Successful Target Interacting Protein Info
UniProt ID
JAK3_HUMAN 
Synonyms Tyrosine-protein kinase JAK3; L-JAK; Leukocyte janus kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
References  Top
REF 1 Identification of NPM-ALK interacting proteins by tandem mass spectrometry. Oncogene. 2004 Apr 8;23(15):2617-29.
REF 2 p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood. 2005 Dec 1;106(12):3907-16.
REF 3 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Mol Cell Biol. 1998 Dec;18(12):6951-61.
REF 4 Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene. 2002 Feb 7;21(7):1038-47.

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