Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T56871 Target Info
Target Name Lysine-specific demethylase 5B (KDM5B)
Synonyms Retinoblastomabinding protein 2 homolog 1; Retinoblastoma-binding protein 2 homolog 1; RBP2H1; RBP2-H1; RBBP2H1; PLU1; PLU-1; Lysinespecific demethylase 5B; Jumonji/ARID domaincontaining protein 1B; Jumonji/ARID domain-containing protein 1B; JARID1B; Histone demethylase JARID1B; Cancer/testis antigen 31; CT31
Target Type Literature-reported Target
Gene Name KDM5B
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
KDM5B_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 SUMO-protein ligase CBX4 (CBX4) Interacting Protein Interacting Protein Info
UniProt ID
CBX4_HUMAN 
Synonyms NBP16; PC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [1]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Reconstituted Complex [4]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Paired box protein Pax-9 (PAX9) Interacting Protein Interacting Protein Info
UniProt ID
PAX9_HUMAN 
Synonyms STHAG3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [7]
4 Yeast two hybrid [6]
Interacting Protein Name Forkhead box protein G1 (FOXG1) Interacting Protein Interacting Protein Info
UniProt ID
FOXG1_HUMAN 
Synonyms BF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF.1; HBF.2; HBF.3; HBF.G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Yeast two hybrid [6]
Interacting Protein Name Homeobox protein CDX-2 (CDX2) Interacting Protein Interacting Protein Info
UniProt ID
CDX2_HUMAN 
Synonyms CDX.3; CDX2/AS; CDX3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
References  Top
REF 1 The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. BMB Rep. 2009 Mar 31;42(3):154-9.
REF 2 SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase. Epigenetics. 2013 Nov;8(11):1162-75.
REF 3 Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7541-6.
REF 4 Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Res. 2011 Nov 1;71(21):6899-908.
REF 5 Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer. 2007 Jul 15;121(2):265-75.
REF 6 Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J Biol Chem. 2003 Jun 6;278(23):20507-13.
REF 7 RBP2-H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells. Int J Cancer. 2008 Mar 1;122(5):1047-57.
REF 8 CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPAR signaling. J Clin Invest. 2013 Jan;123(1):299-314.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.