Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T58178 Target Info
Target Name Glutamate receptor ionotropic kainate 2 (GRIK2)
Synonyms Glutamate receptor ionotropic, kainate 2; Glutamate receptor 6; GluR6; GluR-6; GluK2; Excitatory amino acid receptor 4; EAA4
Target Type Literature-reported Target
Gene Name GRIK2
Biochemical Class Glutamate-gated ion channel
UniProt ID
GRIK2_HUMAN 
Target Interacting Proteins  Top
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Presynaptic density protein 95 (DLG4) Clinical trial Target Interacting Protein Info
UniProt ID
DLG4_HUMAN 
Synonyms Synapse-associated protein 90; SAP-90; SAP90; PSD-95; PSD95; Postsynaptic density-95; Postsynaptic density protein 95; Disks large homolog 4; Discs, large homolog 4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [1]
4 Reconstituted Complex [2]
Other proteins [+] 1 Other proteins +
Interacting Protein Name PRKCA-binding protein (PICK1) Interacting Protein Interacting Protein Info
UniProt ID
PICK1_HUMAN 
Synonyms PICK; PRKCABP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [1]
4 Yeast two hybrid [1]
References  Top
REF 1 Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron. 2003 Feb 20;37(4):625-38.
REF 2 SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron. 1998 Oct;21(4):727-39.
REF 3 The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors. Neuropharmacology. 2008 Dec;55(7):1131-9.

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