Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T62548 Target Info
Target Name Beta-adrenergic receptor kinase 1 (ADRBK1)
Synonyms GRK2; G-protein coupled receptor kinase 2; BetaARK1; Beta-ARK-1; Beta ARK1
Target Type Patented-recorded Target
Gene Name GRK2
Biochemical Class Kinase
UniProt ID
ARBK1_HUMAN 
Target Interacting Proteins  Top
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
References  Top
REF 1 The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic... J Biol Chem. 2001 Jun 29;276(26):24005-14.
REF 2 Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. Biochemistry. 1996 Apr 2;35(13):4155-60.
REF 3 The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Glia. 2015 Dec;63(12):2327-39.
REF 4 Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2. J Biol Chem. 2011 Jan 14;286(2):1165-73.

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