Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63966 Target Info
Target Name Vascular endothelial growth factor receptor 1 (FLT-1)
Synonyms Vascular permeability factor receptor; VEGFR1; VEGFR-1; VEGF-1 receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT; FLT
Target Type Successful Target
Gene Name FLT1
Biochemical Class Kinase
UniProt ID
VGFR1_HUMAN 
Target Interacting Proteins  Top
Growth factors [+] 2 Growth factors +
Interacting Target Name Vascular endothelial growth factor A (VEGFA) Successful Target Interacting Protein Info
UniProt ID
VEGFA_HUMAN 
Synonyms VPF; VEGF-A; VEGF; Vascular permeability factor; Vascular endothelial growth factor A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Interacting Target Name Vascular endothelial growth factor B (VEGFB) Successful Target Interacting Protein Info
UniProt ID
VEGFB_HUMAN 
Synonyms VRF; VEGF-related factor; VEGF-B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [3]
Kinases [+] 1 Kinases +
Interacting Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target Interacting Protein Info
UniProt ID
VGFR2_HUMAN 
Synonyms VEGFR-2; VEGFR2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; FLK-1; FLK1; Fetal liver kinase 1; CD309
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [5]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. Cell Signal. 2012 Jan;24(1):214-23.
REF 3 Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11709-14.
REF 4 N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain. PLoS One. 2014 Nov 11;9(11):e112794.
REF 5 Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat Med. 2003 Jul;9(7):936-43.

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