Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T65501 Target Info
Target Name DNA [cytosine-5]-methyltransferase 3B (DNMT3B)
Synonyms M.HsaIIIB; Dnmt3b; DNA methyltransferase HsaIIIB; DNA methyltransferase 3B; DNA MTase HsaIIIB; DNA (cytosine-5)-methyltransferase 3B
Target Type Clinical trial Target
Gene Name DNMT3B
Biochemical Class Methyltransferase
UniProt ID
DNM3B_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Sucrose nonfermenting protein 2 homolog (SMARCA5) Interacting Protein Interacting Protein Info
UniProt ID
SMCA5_HUMAN 
Synonyms ISWI; SNF2H; WCRF135; hISWI; hSNF2H
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-purification [2]
3 Reconstituted Complex [1]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [3]
3 Co-purification [2]
4 Reconstituted Complex [1]
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [1]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Interacting Protein Info
UniProt ID
DNMT1_HUMAN 
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [5]
4 Reconstituted Complex [6]
Interacting Target Name DNA [cytosine-5]-methyltransferase 3A (DNMT3A) Patented-recorded Target Interacting Protein Info
UniProt ID
DNM3A_HUMAN 
Synonyms M.HsaIIIA; Dnmt3a; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA (cytosine-5)-methyltransferase 3A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [6]
Other proteins [+] 1 Other proteins +
Interacting Target Name DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) Patented-recorded Target Interacting Protein Info
UniProt ID
DNM3L_HUMAN 
Synonyms DNA (cytosine-5)-methyltransferase 3-like
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Co-localization [10]
3 Reconstituted Complex [10]
4 Yeast two hybrid [11]
References  Top
REF 1 DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun. 2004 May 28;318(2):544-55.
REF 2 Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res. 2004 May 17;32(9):2716-29.
REF 3 The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Oncogene. 2014 Apr 24;33(17):2157-68.
REF 4 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3.
REF 5 Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell. 2011 Nov 15;20(5):606-19.
REF 6 Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J. 2002 Aug 1;21(15):4183-95.
REF 7 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 8 Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004 Jan 29;32(2):598-610.
REF 9 DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction. J Biol Chem. 2004 Jun 25;279(26):27816-23.
REF 10 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFB complex in the (de-)methylation of TRAF1. Biochimie. 2014 Sep;104:36-49.
REF 11 Interactions within the mammalian DNA methyltransferase family. BMC Mol Biol. 2003 May 30;4:7.

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