Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66161 | Target Info | |||
| Target Name | Filamin A (FLNA) | ||||
| Synonyms | Nonmuscle filamin; Non-muscle filamin; Filamin-A; Filamin-1; Filamin 1; FLN1; FLN-A; FLN; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | FLNA | ||||
| Biochemical Class | Dystrophin protein | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
| Interacting Protein Name | Filamin-B (FLNB) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ABP.278; ABP.280; AOI; FH1; FLN.B; FLN1L; LRS1; SCT; TABP; TAP | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Co-fractionation | [3] | |||
| 4 | Yeast two hybrid | [2] | |||
| G-protein-coupled receptors | [+] 2 G-protein-coupled receptors | + | |||
| Interacting Target Name | Melatonin receptor type 1A (MTNR1A) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Mel-1A-R; Mel1AR; Mel1a receptor | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| 2 | Reconstituted Complex | [5] | |||
| 3 | Yeast two hybrid | [5] | |||
| Interacting Target Name | Extracellular calcium-sensing receptor (CASR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PCaR1; Parathyroid cell calcium-sensing receptor 1; Parathyroid Cell calcium-sensing receptor; Parathyroid cell calciumreceptor; Parathyroid calcium receptor; hCasR; GPRC2A; CaSR; CaR | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| 3 | Yeast two hybrid | [7] | |||
| Integrins | [+] 1 Integrins | + | |||
| Interacting Target Name | Integrin alpha-4/beta-1 (ITGA4/B1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Alpha 4 beta 1 integrin; alpha(4)beta(1) integrin | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [8] | |||
| 2 | Reconstituted Complex | [9] | |||
| 3 | Yeast two hybrid | [8] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Target Name | Platelet glycoprotein Ib alpha (CD42b) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Platelet glycoprotein Ib alpha chain; GPIb-alpha; GPIbalpha; GPIbA; GP-Ib alpha; GPIb alpha; Glycoprotein Ibalpha; Glycocalicin; Antigen CD42b-alpha; Antigen CD42balpha | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [10] | |||
| 2 | Co-localization | [11] | |||
| Interacting Target Name | Beta-arrestin-2 (ARRB2) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Non-visual arrestin-3; Betaarrestin2; Arrestin beta-2; Arrestin beta2; ARR2; ARB2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [12] | |||
| 2 | Affinity Capture-Western | [13] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
| REF 2 | Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002 Nov 1;11(23):2845-54. | ||||
| REF 3 | A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81. | ||||
| REF 4 | Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics. 2007 May;6(5):835-44. | ||||
| REF 5 | Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res. 2016 Jan;60(1):95-108. | ||||
| REF 6 | Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J Biol Chem. 2001 Sep 14;276(37):34871-9. | ||||
| REF 7 | Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J Biol Chem. 2001 Sep 14;276(37):34880-7. | ||||
| REF 8 | Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. J Biol Chem. 1998 Sep 4;273(36):23304-12. | ||||
| REF 9 | Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002 Jan 21;156(2):361-76. | ||||
| REF 10 | Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem. 2002 Jan 18;277(3):2151-9. | ||||
| REF 11 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 12 | Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6. | ||||
| REF 13 | beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18061-6. | ||||
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