Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T68009 Target Info
Target Name Vascular endothelial cadherin (CDH5)
Synonyms VE-cadherin; VE-cad; Cadherin-5; CD144 antigen; CD144; 7B4 antigen
Target Type Literature-reported Target
Gene Name CDH5
Biochemical Class Cadherin protein
UniProt ID
CADH5_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [1]
2 Yeast two hybrid [2]
Other proteins [+] 4 Other proteins +
Interacting Target Name Beta-catenin (CTNNB1) Successful Target Interacting Protein Info
UniProt ID
CTNB1_HUMAN 
Synonyms Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
Interacting Protein Name Catenin alpha-1 (CTNNA1) Interacting Protein Interacting Protein Info
UniProt ID
CTNA1_HUMAN 
Synonyms CAP102
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
Interacting Protein Name Catenin delta-1 (CTNND1) Interacting Protein Interacting Protein Info
UniProt ID
CTND1_HUMAN 
Synonyms CAS; CTNND; P120CAS; P120CTN; p120; p120(CAS); p120(CTN)
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
Interacting Protein Name Plakophilin-4 (PKP4) Interacting Protein Interacting Protein Info
UniProt ID
PKP4_HUMAN 
Synonyms p0071
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [10]
References  Top
REF 1 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 2 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro. Exp Cell Res. 1997 Dec 15;237(2):347-56.
REF 5 Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1330-8.
REF 6 Apolipoprotein(a) stimulates nuclear translocation of -catenin: a novel pathogenic mechanism for lipoprotein(a). Mol Biol Cell. 2013 Feb;24(3):210-21.
REF 7 Mediating effects of aryl-hydrocarbon receptor and RhoA in altering brain vascular integrity: the therapeutic potential of statins. Am J Pathol. 2012 Jul;181(1):211-21.
REF 8 An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation. Exp Cell Res. 2002 Mar 10;274(1):35-44.
REF 9 Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sci. 1997 Sep;110 ( Pt 17):2065-77.
REF 10 The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein. J Biol Chem. 2003 Jan 17;278(3):1774-83.

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